博文
Hal@MoO3-x nanocomposite for NIR-I photothermal antibacteri
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aHunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, China
bEngineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, 571199, China
Volume 295, January 2027, 108422
Received 23 July 2026, Revised 27 September 2026, Accepted 7 October 2026, Available online 19 October 2026, Version of Record 19 October 2026.
Highlights
•A multifunctional Hal@MoO3-x nanocomposite was fabricated via an in-situgrowth method for wound dressing applications.
•The nanocomposite exhibits superior NIR-I photo-thermal conversionand high antibacterial efficiency under 980 nm laser irradiation.
•Hal@MoO3-x -NIR-I accelerates in vivo wound healing with re-epithelialization and biosafety, showing potential for clinical translation.
This work developed a novel multifunctional heterojunction nanocomposite (Hal@MoO3-x) for wound healing, which is fabricated the via in-situ growth of MoO3-x nanocrystals within the inner cavities and on the outer surface of halloysite nanotubes (Hal). Interfacial interactions at the Hal/MoO3-x heterojunction markedly improved light absorption and photo-thermal conversion properties in the NIR-I region. Under 980 nm laser irradiation at 5 W/cm2, the nanocomposite achieved a rapid temperature increase of 27 °C within 10 min and demonstrated outstanding photo-thermal cycling stability. In vitro antibacterial assays revealed a 99% antibacterial efficiency against S. aureus, with bacterial viability reduced to nearly zero upon NIR-I exposure. In a mouse full-thickness skin defect model, the Hal@MoO3-x nanocomposite exhibited excellent wound-healing promotion effect under NIR-I irradiation, achieving a high wound healing rate (96%) within 10 days. Histopathological analysis and body weight monitoring confirmed the absence of obvious systemic toxicity, affirming desirable biosafety. This nanoplatform effectively overcomes the limitations of conventional dressings, such as weak antibacterial activity and single functionality, offering an integrated solution for rapid wound regeneration.
Fig. 1. Illustration of the preparation, antibacterial activity and wound healing effect of novel Hal@MoO3-x nanocomposites.
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