博文
HIF-1，SDF-1，VEGF mRNA的影响
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损伤的组织局部为低氧环境,激活对缺氧敏感的转录因子HIF-1,调控SDF-1表达增多,并形成适合干细胞存在及生长的微环境,通过SDF-1促进CXCR4阳性的干细胞黏附、迁移和归巢到缺氧部位,参与血管形成。
CeradiniDJ, KulkarniAR, CallaghanMJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 [ J ]. NatMed, 2004, 10 (8) : 858 - 864.
SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension. HIF-1-induced SDF-1 expression increases the adhesion, migration and homing of circulating CXCR4-positive progenitor cells to ischemic tissue.
Blockade of SDF-1 in ischemic tissue or CXCR4 on circulating cells prevents progenitor cell recruitment to sites of injury. These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1.
缺氧——HIF-1升高——SDF-1升高——诱导具有CXC4受体的BMC迁移到心脏梗死区。
缺氧——HIF-1升高——SDF-1升高——诱导具有CXC4受体的BMC迁移到心脏梗死区。
HIF-1可以调节SDF和VEGF的基因表达，使它们表达量起相应的变化。
https://blog.sciencenet.cn/blog-468039-406030.html
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