Science Blog of Dr. Yuan分享 http://blog.sciencenet.cn/u/albumns This blog is mainly on Molecular molecular modelling and simulations

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分享 New Webpage of Prof. Vogel Launched
2018-10-18 18:13
The new webpage of Prof. Horst vogel is launched. http://hv.gpcrm.org
个人分类: 未分类|218 次阅读|没有评论
分享 Nobel Prize in Chemistry 2018
2018-10-3 17:57
The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter. Sir Gregory Winter, awarded the #NobelPrize in Chemistry, ...
个人分类: 科研笔记|399 次阅读|没有评论
分享 The first Frizzled class GPCR structure was resolved
2018-8-24 03:20
Crystal structure of the Frizzled 4 receptor in a ligand-free state. Shifan Yang, Yiran Wu, Ting-Hai Xu, Parker W. de Waal, Yuanzheng He, Mengchen Pu, Yuxiang Chen, Zachary J. DeBruine, Bingjie Zhang, Saheem A. Zaidi, Petr Popov, Yu Guo, Gye Won Han, Yang Lu, Kelly Suino-Powell, Shao ...
390 次阅读|没有评论
分享 Exploring a new ligand binding site of GPCR by MD simulation
2018-7-17 22:33
Chemical Science (2018) doi:10.1039/C8SC01680A full text Identifying a target ligand binding site is an important step for structure-based rational drug design as shown here for G protein-coupled receptors (GPCRs), which are among the most popular drug targets. We applied l ...
个人分类: 未分类|470 次阅读|没有评论
分享 First GPCR-directed antibody passes approval milestone
2018-7-8 02:15
Nature Reviews Drug Discovery | Published online 28 Jun 2018; doi:10.1038/nrd.2018.103 https://www.nature.com/articles/nrd.2018.103 Amgen’s erenumab recently secured FDA approval as the first G protein-coupled receptor-targeted antibody. More of these biologics are on the way, de ...
个人分类: 好文转载|395 次阅读|没有评论
分享 Next generation VR for molecular visualization and modelling
2018-7-6 15:06
Movie file VR.mp4
378 次阅读|没有评论
分享 The first GPCR-Go complex structure resolved
2018-6-25 02:58
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go Nature (2018) Abstract G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to a small number of ...
个人分类: 科研笔记|634 次阅读|没有评论
分享 The first GPCR-Gi complex structure resolved
2018-6-15 01:02
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Nature (2018) Published:13 June 2018 Abstract G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with d ...
个人分类: 好文转载|837 次阅读|没有评论
分享 openSUSE Leap 15.0 released
2018-5-28 04:28
Download: https://software.opensuse.org/distributions/leap Release notes Release Notes REPORT BUG # openSUSE Leap is a free and Linux-based operating system for your PC, Laptop or Server. You can surf the Web, manage your e-mails and photos, do office work, play videos or mu ...
个人分类: Linux相关|793 次阅读|没有评论

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