Science Blog of Dr. Yuan分享 This blog is mainly on Molecular molecular modelling and simulations


分享 研究助理,博士后,博士和硕士招聘
2019-3-13 17:18
中科院深圳先进技术研究院招聘( 新药发现中心 袁曙光课题组) Postdoc/PhD/Master positions in computational biology and modern drug discovery(English is blow) 本招聘信息长期有效。 一、招聘岗位 : 单位介绍:中国科学院深圳先进技术研究院(先进院)是一所以科研为主的集科研、教 ...
2977 次阅读|没有评论
分享 New Webpage of Prof. Vogel Launched
2018-10-18 18:13
The new webpage of Prof. Horst vogel is launched.
个人分类: 未分类|509 次阅读|没有评论
分享 Nobel Prize in Chemistry 2018
2018-10-3 17:57
The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter. Sir Gregory Winter, awarded the #NobelPrize in Chemistry, ...
个人分类: 科研笔记|719 次阅读|没有评论
分享 The first Frizzled class GPCR structure was resolved
2018-8-24 03:20
Crystal structure of the Frizzled 4 receptor in a ligand-free state. Shifan Yang, Yiran Wu, Ting-Hai Xu, Parker W. de Waal, Yuanzheng He, Mengchen Pu, Yuxiang Chen, Zachary J. DeBruine, Bingjie Zhang, Saheem A. Zaidi, Petr Popov, Yu Guo, Gye Won Han, Yang Lu, Kelly Suino-Powell, Shao ...
625 次阅读|没有评论
分享 Exploring a new ligand binding site of GPCR by MD simulation
2018-7-17 22:33
Chemical Science (2018) doi:10.1039/C8SC01680A full text Identifying a target ligand binding site is an important step for structure-based rational drug design as shown here for G protein-coupled receptors (GPCRs), which are among the most popular drug targets. We applied l ...
个人分类: 未分类|808 次阅读|没有评论
分享 First GPCR-directed antibody passes approval milestone
2018-7-8 02:15
Nature Reviews Drug Discovery | Published online 28 Jun 2018; doi:10.1038/nrd.2018.103 Amgen’s erenumab recently secured FDA approval as the first G protein-coupled receptor-targeted antibody. More of these biologics are on the way, de ...
个人分类: 好文转载|607 次阅读|没有评论
分享 Next generation VR for molecular visualization and modelling
2018-7-6 15:06
Movie file VR.mp4
562 次阅读|没有评论
分享 The first GPCR-Go complex structure resolved
2018-6-25 02:58
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go Nature (2018) Abstract G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to a small number of ...
个人分类: 科研笔记|805 次阅读|没有评论
分享 The first GPCR-Gi complex structure resolved
2018-6-15 01:02
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Nature (2018) Published:13 June 2018 Abstract G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with d ...
个人分类: 好文转载|1063 次阅读|没有评论

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