Science Blog of Dr. Yuan分享 http://blog.sciencenet.cn/u/albumns This blog is mainly on Molecular molecular modelling and simulations

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分享 PhD and Postdoc positions
2018-11-25 02:53
Several PhD and Postdoc positions are avaible in Prof. Slawomir Filipek's lab (http://www.biomodellab.eu) at the University of Warsaw in Poland. Prof. Slawomir Filipek is mainly working on the biophysic of GPCR, ion channels as well asgraphene.Prof.Slawomir Filipek is a ...
个人分类: 科研笔记|224 次阅读|没有评论
分享 New Webpage of Prof. Vogel Launched
2018-10-18 18:13
The new webpage of Prof. Horst vogel is launched. http://hv.gpcrm.org
个人分类: 未分类|319 次阅读|没有评论
分享 Nobel Prize in Chemistry 2018
2018-10-3 17:57
The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter. Sir Gregory Winter, awarded the #NobelPrize in Chemistry, ...
个人分类: 科研笔记|523 次阅读|没有评论
分享 The first Frizzled class GPCR structure was resolved
2018-8-24 03:20
Crystal structure of the Frizzled 4 receptor in a ligand-free state. Shifan Yang, Yiran Wu, Ting-Hai Xu, Parker W. de Waal, Yuanzheng He, Mengchen Pu, Yuxiang Chen, Zachary J. DeBruine, Bingjie Zhang, Saheem A. Zaidi, Petr Popov, Yu Guo, Gye Won Han, Yang Lu, Kelly Suino-Powell, Shao ...
472 次阅读|没有评论
分享 Exploring a new ligand binding site of GPCR by MD simulation
2018-7-17 22:33
Chemical Science (2018) doi:10.1039/C8SC01680A full text Identifying a target ligand binding site is an important step for structure-based rational drug design as shown here for G protein-coupled receptors (GPCRs), which are among the most popular drug targets. We applied l ...
个人分类: 未分类|562 次阅读|没有评论
分享 First GPCR-directed antibody passes approval milestone
2018-7-8 02:15
Nature Reviews Drug Discovery | Published online 28 Jun 2018; doi:10.1038/nrd.2018.103 https://www.nature.com/articles/nrd.2018.103 Amgen’s erenumab recently secured FDA approval as the first G protein-coupled receptor-targeted antibody. More of these biologics are on the way, de ...
个人分类: 好文转载|473 次阅读|没有评论
分享 Next generation VR for molecular visualization and modelling
2018-7-6 15:06
Movie file VR.mp4
434 次阅读|没有评论
分享 The first GPCR-Go complex structure resolved
2018-6-25 02:58
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go Nature (2018) Abstract G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to a small number of ...
个人分类: 科研笔记|689 次阅读|没有评论
分享 The first GPCR-Gi complex structure resolved
2018-6-15 01:02
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Nature (2018) Published:13 June 2018 Abstract G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with d ...
个人分类: 好文转载|913 次阅读|没有评论

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