Glucose-TOR signaling regulates PIN2 stability to orchestrate auxin gradient and cell expansion in Arabidopsis root

第一作者：Xinbo Yuan

第一单位：中科院分子植物科学卓越创新中心

通讯作者：Yan Xiong

 Abstract 

背景回顾：The plant growth hormone auxin controls cell identity, cell division, and expansion. In the primary root of Arabidopsis there is a robust auxin gradient with a peak concentration at the tip of the meristem and a significant decrease throughout the elongation zone.

提出问题：The molecular mechanisms of how such a steep auxin gradient is established and maintained, and how this auxin gradient within the root dynamically adjusts in response to environmental stimuli are still largely unknown.

主要发现：Here, using a large-scale Arabidopsis mutant screening, we described the identification of PIN2 (PIN-FORMED 2), an auxin efflux facilitator, as a key downstream regulator in glucose-TOR (target of rapamycin) energy signaling.

结果1-TOR2与PIN2：We demonstrate that glucose-activated TOR phosphorylates and stabilizes PIN2 and therefore influences the gradient distribution of PIN2 in the Arabidopsis primary root.

结果2-TOR2或PIN2失调：Interestingly, dysregulation of TOR or PIN2 disrupts the glucose-promoted low auxin region located in the elongation zone that is essential for cell elongation.

结论：Taken together, our results shed light on how carbon and metabolic status can be tightly integrated with the hormone-driven processes to orchestrate complex plant growth programs.

 通讯作者 

doi: https://doi.org/10.1073/pnas.2015400117

Journal: PNAS

Published date: Dec 22, 2020