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Current Biology:猴面花花瓣斑点形成的分子机制

已有 439 次阅读 2020-2-25 04:21 |个人分类:每日摘要|系统分类:论文交流

Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns

First author: Baoqing Ding; Affiliations: University of Connecticut  (康涅狄格大学): Storrs, USA

Corresponding author: Yao-Wu Yuan

Many organisms exhibit visually striking spotted or striped pigmentation patterns. Developmental models predict that such spatial patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop interact. At its simplest, this self-organizing network only requires one self-activating activator that also activates a repressor, which inhibits the activator and diffuses to neighboring cells. However, the molecular activators and inhibitors fully fitting this versatile model remain elusive in pigmentation systems. Here, we characterize an R2R3-MYB activator and an R3-MYB repressor in monkeyflowers (Mimulus). Through experimental perturbation and mathematical modeling, we demonstrate that the properties of these two proteins correspond to an activator-inhibitor pair in a two-component, reaction-diffusion system, explaining the formation of dispersed anthocyanin spots in monkeyflower petals. Notably, disrupting this pattern impacts pollinator visitation. Thus, subtle changes in simple activator-inhibitor systems are likely essential contributors to the evolution of the remarkable diversity of pigmentation patterns in flowers.


通讯:袁耀武 (https://monkeyflower.uconn.edu)



doi: https://doi.org/10.1016/j.cub.2019.12.067

Journal: Current Biology

Published date: February 20, 2020

p.s. 猴面花:https://www.sciencemag.org/news/2019/08/meet-monkeyflower-weed-may-hold-key-zebra-stripes-and-other-biological-mysteries



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