A principal investigator (PI) is the lead scientist or engineer for a particular well-defined science (or other research) project, such as a laboratory study or clinical trial.
In the context of federal funding from agencies such as the NIH or the NSF, the PI is the person who takes direct responsibility for completion of a funded project, directing the research and reporting directly to the funding agency.[1] For small projects (which might involve 1-5 people) the PI is typically the person who conceived of the investigation, but for larger projects the PI may be selected by a team to obtain the best strategic advantage for the project.
In the context of a clinical trial a PI may be an academic working with grants from NIH or other funding agencies, or may be effectively a contractor for a pharmaceutical company working on testing the safety and efficacy of new medicines.
The term is often incorrectly spelled as "principle investigator", which would refer to someone who investigates principles or precepts. The correct term is "principal investigator", where "principal" means 'primary' or 'leading'.
PRINCIPAL INVESTIGATOR/PROJECT DIRECTOR (PI/PD) is the individual designated by the grantee, and approved by NSF, who will be responsible for the scientific or technical direction of the project. The term "Principal Investigator" generally is used in research projects, while the term "Project Director" generally is used in science and engineering education and other projects.