Nat Genet. 2014 Jul;46(7):714-21. doi: 10.1038/ng.3007. Epub 2014 Jun 8. Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. Chen W 1 , Gao Y 1 , Xie W 1 , Gong L 1 , Lu K 1 , Wang W 2 , Li Y 2 , Liu X 3 , Zhang ...
这篇文章提供了一个分析实例. Lessons from Dwarf8 on the Strengths and Weaknesses of Structured Association Mapping( http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003246 )Sara J. Larsson,Alexander E. Lipka,Edward S. Buckler
我感觉植物的关联作图应该照这篇文章的思路来做.关联作图和连锁作图结合,还有转基因互补实验.所以这个可以当成一个范例.当然信不信由你,反正我是信了! Genome-Wide Association Studies Identify Heavy Metal ATPase3 as the Primary Determinant of Natural Variation in Leaf Cadmium in Arabido ...
Genotype–phenotype mapping in a post-GWAS world 呵呵,这篇文章出现了一个新词(对我来说比较新):post-GWAS.的确应该考虑后关联作图时代的问题了.GWAS的问题是什么呢?Genome-wide association studies (GWAS) statistically connect genotypes to phenotypes, without any recourse to known mole ...
Evolution and Association Analysis of Ghd7 in Rice pone.0034021.pdf 这个研究可以看成是一个特定基因的关联分析.一个基因有不同的等位基因(单倍型),那么哪个SNP或单倍型和哪种性状相关呢?可以这样来分析.Ghd7本来是个多效基因,其中包括产量,株高和抽穗期.所以,该研究中考察的性状也为株高, ...
1.Durand, E., Bouchet, S., Bertin, P., Ressayre, A., Jamin, P., Charcosset, A., Dillmann, C., and Tenaillon, M. I. (2012) Flowering Time in Maize: Linkage and Epistasis at a Major Effect Locus, Genetics 190, 1547-1562. http://www.genetics.org/content/190/4/1547.abstract?etoc ...
Browning, S. R., and Thompson, E. A. (2012) Detecting Rare Variant Associations by Identity-by-Descent Mapping in Case-Control Studies, Genetics 190, 1521-1531. 相关概念:identity-by-descent (IBD) 维基的解释: Two or more alleles are identical by descent (IBD) if they are identical c ...
Admixture Mapping Comes of Age * Annual Review of Genomics and Human Genetics Vol. 11: 65-89 (Volume publication date September 2010) First published online as a Review in Advance on July 1, 2010 DOI: 10.1146/annurev-genom-082509-141523 Admixture mapping is based on the hypothesis t ...
这是一个例子: Targeted association analysis identified japonica rice varieties achieving Na+/K+ homeostasis without the allelic make-up of the salt tolerant indica variety Nona Bokra Targeted association analysis identified japonica rice varieties achieving Na+K+.pdf ...
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