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氢气治疗apoE基因缺陷动物的动脉硬化

已有 8147 次阅读 2009-2-10 20:20 |个人分类:饮用氢气水|系统分类:科研笔记| 论文, 氢气, 抗氧化, 抗氧化, 抗氧化

这个文章是让动物从出生开始饮含氢水6个月,发现对动脉硬化具有非常理想的治疗效果。

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice


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Ikuroh Ohsawaa, b, Kiyomi Nishimakia, Kumi Yamagataa, Masahiro Ishikawaa and Shigeo Ohtaa, Corresponding Author Contact Information, E-mail The Corresponding Author

aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan

bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki 211-8533, Japan


Received 16 October 2008. 
Available online 6 November 2008.

Abstract

Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H2) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688–694]. Here, we investigated whether drinking H2-dissolved water at a saturated level (H2–water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE−/−), a model of the spontaneous development of atherosclerosis. ApoE−/− mice drank H2–water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H2–water (p = 0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H2-dissolved water has the potential to prevent arteriosclerosis.

Keywords: Antioxidant; ApoE; Arteriosclerosis; Atherogenesis; Dihydrogen; Lifestyle-related disease; Macrophage; Molecular hydrogen; Oxidative stress; Preventive medicine

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