革命性的生物医用金属材料(RMB) ...分享 http://blog.sciencenet.cn/u/郑玉峰 从事新型生物医用金属材料(镁基、铁基、钛基、BMG、纳米晶)研究

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Biomaterials第三篇可降解镁金属文章,今年三篇都是中国的,赞!

已有 3411 次阅读 2015-6-23 17:28 |系统分类:博客资讯

http://www.sciencedirect.com/science/article/pii/S0142961215005451


In vitro and in vivo studies on the degradation of high-purity Mg(99.99wt.%) screw with femoral intracondylar fractured rabbit model

Abstract

High-purity magnesium (HP Mg) takes advantage in no alloying toxic elements and slower degradation rate in lack of second phases and micro-galvanic corrosion. In this study, as rolled HP Mg was fabricated into screws and went through in vitro immersion tests, cytotoxicity test and bioactive analysis. The HP Mg screws performed uniform corrosion behavior in vitro, and its extraction promoted cell viability, bone alkaline phosphatase (ALP) activity, and mRNA expression of osteogenic differentiation related gene, i.e. ALP, osteopontin (OPN) and RUNX2 of human bone marrow mesenchymal stem cells (hBMSCs).

Then HP Mg screws were implanted in vivo as load-bearing implant to fix bone fracture and subsequently gross observation, range of motion (ROM), X-ray scanning, qualitative micro-computed tomography (μCT) analysis, histological analysis, bending-force test and SEM morphology of retrieved screws were performed respectively at 4, 8, 16 and 24 weeks. As a result, the retrieved HP Mg screws in fixation of rabbit femoral intracondylar fracture showed uniform degradation morphology and enough bending force. However, part of PLLA screws was broken in bolt, although its screw thread was still intact. Good osseointegration was revealed surrounding HP Mg screws and increased bone volume and bone mineral density were detected at fracture gap, indicating the rigid fixation and enhanced fracture healing process provided by HP Mg screws. Consequently, the HP Mg showed great potential as internal fixation devices in intra-articular fracture operation.


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