博文
- First GPCR-directed antibody passes approval milestone
- Nature Reviews Drug Discovery | Published online 28 Jun 2018; doi:10.1038/nrd.2018.103 https://www.nature.com/articles/nrd.2018.103 Amgen’s erenumab recently secured FDA approval as the first G protein-coupled receptor-targeted antibody. More of these biologics are on the way, de ...
- The first GPCR-Gi complex structure resolved
- Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Nature (2018) Published:13 June 2018 Abstract G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with d ...
- a postdoc position
- About the Agency for Science, Technology and Research (A*STAR) The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that spearheads economic oriented research to advance scientific discovery and develop innovative technology. Through open innovati ...
- Crystal structures of adiponectin receptors released
- 热度 1
- Nature 520, 312–316 (16 April 2015) doi:10.1038/nature14301 Full text Abstract Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5′ AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby c ...
- 2014 FDA drug approvals
- From Nature Reviews Drug Discovery 14, 77–81(2015) doi:10.1038/nrd4545 Drug (brand name) Sponsor Properties Indications Review types Dapagliflozin (Farxiga) AstraZeneca SGLT2 inhibitor Type 2 diabetes S Tasimelteon (Hetlioz) Vanda Melatonin-receptor agonist ...
- BioVersys works to bring antinbiotic resistance to an end
- From http://www.venturekick.ch 9 December 2014 - In May this year, BioVersys started a project in collaboration with Lille University and GlaxoSmithKline to develop a preclinical candidate for the treatment of tuberculosis, a disease that alone kills more than 1.5 million people each ...
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