Background The genome is normally organized into A/B compartments, TADs, and chromatin loops, but the mechanisms that actually drive compartment formation and separation are still not fully understood. This is especially unclear because, in interphase, many factors act at the same time, inclu ...
肾细胞癌基因转位导致TFE3融合基因形成可促进肿瘤恶性进展。TFE3常与PRCC、NONO、SFPQ等基因发生融合，形成新的融合蛋白。然而TFE3融合蛋白如何驱动肿瘤恶性进展尚不清楚。近期研究表明，TFE3-NONO融合蛋白可形成相分离凝聚体，并促进融合蛋白稳定性其在肿瘤染色质调节及基因转录调控中的作用尚不清楚。 最近，Dengfeng C ...
2025 年诺贝尔生理学或医学奖：免疫系统的平衡与智慧
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