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特刊：Extracellular vesicles in cancer progression

期刊：BMC Cancer

客座编辑：Orazio Fortunato, Irina Matei & Chunlin Ou

Over the last few decades it has become clear that the cross-talk between neoplastic cells and the tumour microenvironment, comprising resident and infiltrating host cells, extracellular matrix proteins and secreted factors, plays a key role in tumour progression and therapeutic resistance. The dynamic interaction between cancer cells and the tumour microenvironment can be mediated by the bi-directional release and uptake of extracellular vesicles. Defined as lipid bilayer enclosed vesicles found in several biological fluids, extracellular vesicles are currently investigated for their ability to carry and deliver, at both short and long distances, several bioactive molecules, including nucleic acids, lipids and membrane-bound and cytosolic proteins, which could potentially influence many aspects of cancer progression. 

• In recognition of the growing field of research, BMC Cancer have launched this collection to bring together research on:

• The role of extracellular vesicles in modulating the behaviour of resident and host cells in the tumour microenvironment.

• The role of circulating extracellular vesicles in setting up the pre-metastatic niche

• The role of extracellular vesicles in therapeutic resistance.

• Investigating the cargos of cancer-related extracellular vesicles as potential diagnostic, prognostic and predictive biomarkers.

• Changes in the mechanisms of extracellular vesicles biogenesis, release and uptake in cancer.

• The use of extracellular vesicles as delivery vehicles for therapeutics.

• The role of extracellular vesicles as therapeutic targets.

• Advances in the isolation and characterisation of cancer-related extracellular vesicles.

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特刊：Climate impacts on health

期刊：BMC Public Health

客座编辑：Meghnath Dhimal, Ramesh Dhiman & Shengzhi Sun

Climate change is a significant threat to global and human health, affecting both mental and physical health, and to the function of health systems, particularly in low-income and disadvantaged communities which are contributing least to its causes. Between 2030 and 2050, climate change is expected to cause approximately 250,000 additional deaths per year, from malnutrition, malaria, diarrhea and heat stress and it is likely to have substantial, long term impacts on human health and productivity.

In support of tackling the urgent climate change crisis and SDG13 (Climate Action), BMC Public Health has launched this collection which welcomes submissions addressing:

• The health effects of extreme weather events

• The impact of climate change on infectious disease risks

• The impact of climate change on non-communicable diseases

• The impact of climate change on marginalized communities

• The threats of climate change to mental health

• Climate change and social justice

• Climate change and global health equity

• Climate change, gender and health

• The health benefits of climate change policy

• Climate resilient efforts to reduce adverse impacts

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特刊：Multimorbidity in Primary Care

期刊：BMC Primary Care

客座编辑：Lloyd D Hughes, Filipe Prazeres, Ingmar Schäfer & Jean Karl Soler

BMC Primary Care is calling for submissions to our Collection on Multimorbidity in Primary Care.

This collection welcomes submissions that contribute to our understanding of multimorbidity, including:

• Multimorbidity through the lenses of the patient, family, carers, and primary care worker

• Complexity in the context of multimorbidity

• Clustering of multimorbidity patterns across the life cycle

• Physical-mental health multimorbidity

• Quality of life measures for patients with multimorbidity

• Social determinants of health and vulnerable populations with multimorbidity

• Evidence-based treatment strategies and interventions for patients with multimorbidity

• International perspectives on multimorbidity, including challenges, best practice, and opportunities for change

• Measuring the quality of care for patients with multimorbidity (e.g. quality indicators)

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特刊：Biodiversity, Ecosystem Services and Sustainable Development

期刊：BMC Ecology and Evolution

客座编辑：Gary Bucciarelli, Luisa Orsini & Luke Jacobus

Biodiversity helps to ensure a healthy and functioning planet. We depend on biodiversity to facilitate ecosystem services essential for life and our well-being. These include the microorganisms that enrich soil and purify water, the pollinators that give us food, and the plants that absorb carbon dioxide from the atmosphere. However, as the human impact on the planet intensifies, the ability of ecosystems to provide these services is increasingly compromised.

To highlight this issue and support the United Nation’s Sustainable Development Goals (SGDs) 6: Clean water and sanitation, 13: Climate action, 14: Life below water and 15: Life on land, BMC Ecology and Evolution have launched this collection to bring together research on:

• the impact of human activity on biodiversity and the functioning of ecosystems,

• reducing degradation of natural habitats,

• halting biodiversity loss and protecting threatened species,

• sustainable use of terrestrial and aquatic ecosystems,

• the trafficking of protected species and

• the ecological impact of invasive species.

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特刊：The Impact of IoT on Digital Health

期刊：BMC Digital Health

客座编辑：José Alberto Benítez-Andrades & Alessia Paglialonga

The Internet of Things (IoTs) is undoubtedly having a significant impact on the healthcare sector; there are potentially a myriad of benefits to the industry via networks of digital devices collecting, transmitting and storing  health data without the need human-to-human or human-to-computer interaction.

BMC Digital Health is calling for submissions to our Collection on novel developments involving IoT technologies aimed at enhancing healthcare, including, but not limited to, the prediction and diagnosis of health conditions,  treatments,  patient monitoring and healthcare delivery in general. Research exploring the streamlining of healthcare resources and the global impact of IoT technology on healthcare will also be considered.

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特刊：Virtual Reality in Healthcare

期刊：BMC Digital Health

客座编辑：Philippe J. Giabbanelli

Virtual reality (VR) is a relatively new technology that is already proving to be an essential tool to both clinical researchers and medical practitioners. 

BMC Digital Health is calling for submissions to our Collection presenting novel developments and applications of virtual reality in a healthcare setting including, but not limited to, surgery, including robotic surgery, mental health and psychological therapy, pain management and physical therapy. Research exploring the use of VR as a medical training tool and also to raise awareness of health conditions will also be considered.

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特刊：Endocrine disruptors in the environment  

期刊：Scientific Reports

客座编辑：Ella Atlas, Valentina Maria Fernandes Domingues & Demetri D. Spyropoulos

Endocrine disrupting chemicals interfere with various physiological processes, increasing the risk of a wide range of diseases and disorders. Exposure occurs during both adulthood and development – through air, water, foods and beverages, and everyday products like carpeting, furniture, and toiletries. Common endocrine disruptors found in the environment include many chemicals used in manufacturing, such as bisphenol A, per- and polyfluoroalkyl substances, phthalates, and organotins; certain pesticides, such as pyrethroids and organochlorine compounds; pharmaceuticals discharged from wastewater plants; and some heavy metals. While the precise mechanisms are often unclear, associations have been found between these chemicals and male and female infertility; testicular, prostate, and breast cancer; thyroid dysfunction; obesity, insulin resistance, hypertension, and diabetes; and mood and behavioral disorders, among other outcomes. This Collection will highlight epidemiological and experimental studies that investigate these associations and the underlying causes.

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特刊：Post-transcriptional regulation

期刊：Scientific Reports

客座编辑：Claire Francastel, Pooja Gupta & Jose M. Requena

Gene regulation occurs not only at the transcriptional stage, for example via promoter sequence methylation and histone modification, but also post-transcriptionally. A myriad of long and small non-coding RNAs and RNA binding proteins interact with each other and with the messenger RNAs that encode proteins to create an intricate and responsive network of post-transcriptional control. These molecules regulate the production of mRNA variants via alternative splicing, control the rate of mRNA translation by acting as, or interacting with, translation factors, and promote the stability or degradation of mRNA or other RNAs. In addition, non-coding RNAs themselves undergo a range of post-transcriptional modifications that affect their own function, the so-called epitranscriptome. Articles in this Collection will explore the RNA-RNA and RNA-protein interactions that shape post-transcriptional regulation, both in normal physiology and in various pathologies.

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