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Budding yeasts are cheap and easy to maintain and have the ability to proliferate clonally, indefinitely both as haploids and as diploids, and their ploidy levels can readily be changed (Dilorio et al., 1987).
Further, all species are able to hybridize to each other creating viable but near-sterile progeny.
此外,所有物种都能够相互杂交,形成可行但近乎不育的后代。
Budding yeasts have a compact genome(有一个紧凑的基因组) coding for 5000–6000 genes. Having such small genomes and being single-cell organisms, with a rapid generation time (~1.5–3.0 hours per cell division),render yeast cells ideal models (使酵母细胞成为理想的模型)for research of highly complex biological processes. Short generation time enables us to perform evolution experiments (Dujon, 2010), and being unicellular makes yeast available (作为单细胞细胞,酵母是可利用的)to simple cell sorting-based types of analyses.
Also available are libraries of conditional knockouts, overexpression, fluorescent-tagged proteins,
and other variants—all suitable for high-throughput, genome-wide work (Costanzo et al., 2006).
也有条件敲除库,过表达,荧光标记蛋白,和其他变体-所有适合高通量,全基因组的工作。
Not surprisingly, considering their success in nature and under domestication, yeast interspecific
hybrids were reported to show heterosis (杂种优势)(Tirosh et al., 2009). The genetic and molecular basis of heterosis in yeast has received very little attention so far despite its importance for the yeast industry and its potential utility as a model for understanding heterosis in plants and animal breeding. Among the few reports, quantitative trait locus (QTL) mapping of genes involved in yeast growth under high temperatures uncovered a complex locus of three genes, which when heterozygous contributed to heterosis (Steinmetz et al., 2002).
在为数不多的报道中,当杂合子导致杂种优势时,对高温下与酵母生长有关的基因进行定量性状位点(QTL)定位发现了一个由三个基因组成的复杂位点(Steinmetz et al., 2002)。
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