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2022年诺贝尔生理学或医学奖得主Svante Pääbo的科学贡献

已有 1276 次阅读 2022-10-3 19:17 |个人分类:诺贝尔奖|系统分类:观点评述



2022年诺贝尔生理学或医学奖揭晓!

https://news.sciencenet.cn/news/sub24.aspx?id=3942

https://news.sciencenet.cn/htmlnews/2022/10/487249.shtm

科学网直播

https://weibo.com/l/wblive/p/show/1022:2321324819526436127559

北京时间10月3日下午5点33分许,2022年诺贝尔生理学或医学奖揭晓。瑞典科学家Svante Pääbo获奖,以表彰他“ 在灭绝古人类基因组和人类进化方面的发现”。

https://www.163.com/dy/article/HIP941JN05118KMO.html

详解2022诺贝尔生理学或医学奖:他创立了一门全新学科,揭示人类因何独一无二

https://mp.weixin.qq.com/s/et8G1mnTr73xhH2Tw7-mAA



检索到文献344篇   

http://www.pubmedplus.cn/P/SearchQuickResult?wd=9305c979-326b-42d8-9f11-106ad9b0de9f




1.分析人类和灵长类谱系特异性表达变化的候选基因。




Cecilia Lindskog、Martin Kuhlwilm、Armaty Davierwala、Ning Fu、Geeta Hegde、Mathias Uhlén、Sanjay Navani、Svante Päbo、Fredrik Pontén


瑞典乌普萨拉大学生命科学实验室免疫学、遗传学和病理学系,地址:瑞典乌普巴拉SE-751 85,Dag Hammarskjölds väg 20。




蛋白质组研究杂志(P 1535-3907 E 1535-3893)H指数:145 2014 年 13卷 8.期 3596-606 页




项目管理编号:24911366相似文献




文摘 内政部链接 美国化学学会




英 汉


2.肉碱-棕榈酰辅酶a转移酶-1B的表达受顺式作用eQTL的影响,这两个选择用于高体重和低体重的鸡品系。




Sojeong Ka、Ellen Markljung、Henrik Ring、Frank W Albert、Mohammad Harun Or Rashid、Per Wahlberg、Pablo M Garcia Roves、Juleen R Zierath、D Michael Denbow、Svante Pääbo、Paul B Siegel、Leif Andersson、Finn Hallbök


瑞典乌普萨拉大学神经科学系。




生理基因组学(P 1531-2267 E 1094-8341)H指数:101 2013 年 45卷 9期 367-76 页




项目管理编号:23512741相似文献




文摘 内政部链接 阿提蓬牌手表




英 汉


3.线粒体基因组变异与现代人类起源。


M Ingman、H Kaessmann、S Paäbo、U Gyllensten


瑞典乌普萨拉大学医学遗传学科遗传学和病理学系。




性质(P0028-0836 E 0028-0836)H指数:1096 2000 年 408卷 6813期 708-13 页




项目管理编号:11130070相似文献




文摘 内政部链接 自然出版集团Ovid Technologies,股份有限公司。


https://pubmed.ncbi.nlm.nih.gov/11130070/


https://pubmed.ncbi.nlm.nih.gov/?term=P%C3%A4%C3%A4bo+S&cauthor_id=11130070


Nature

2000 Dec 7;408(6813):708-13.

 doi: 10.1038/35047064.

Mitochondrial genome variation and the origin of modern humans

M Ingman 1H KaessmannS PääboU Gyllensten

Affiliations expand

Erratum in

  • Nature 2001 Mar 29;410(6828):611

Abstract

The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate between sites, and the consequence of parallel mutations causing difficulties in the estimation of genetic distance and making phylogenetic inferences questionable. Most comprehensive studies of the human mitochondrial molecule have been carried out through restriction-fragment length polymorphism analysis, providing data that are ill suited to estimations of mutation rate and therefore the timing of evolutionary events. Here, to improve the information obtained from the mitochondrial molecule for studies of human evolution, we describe the global mtDNA diversity in humans based on analyses of the complete mtDNA sequence of 53 humans of diverse origins. Our mtDNA data, in comparison with those of a parallel study of the Xq13.3 region in the same individuals, provide a concurrent view on human evolution with respect to the age of modern humans.

Comment in

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Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa

  • Animals

  • DNA, Mitochondrial*

  • Evolution, Molecular*

  • Genetic Variation*

  • Genome

  • Humans

  • Mitochondria / genetics*

  • Molecular Sequence Data

  • Phylogeny

  • X Chromosome

Substances

  • DNA, Mitochondrial

Associated data

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文献检索分析结果

http://www.pubmedplus.cn/P/SearchQuickResult?wd=ee85202c-7709-4da4-b811-556061dbdbd9

01.无法确认3 篇0.872%
02.20227 篇2.035%
03.20215 篇1.453%
04.202010 篇2.907%
05.201910 篇2.907%
06.20186 篇1.744%
07.201710 篇2.907%
08.201614 篇4.070%
09.201511 篇3.198%
10.201416 篇4.651%
11.201310 篇2.907%
12.201210 篇2.907%
13.201111 篇3.198%
14.201013 篇3.779%
15.20099 篇2.616%
16.200810 篇2.907%
17.200710 篇2.907%
18.200614 篇4.070%
19.200515 篇4.360%
20.200415 篇4.360%
21.200311 篇3.198%
22.20028 篇2.326%
23.20018 篇2.326%
24.20008 篇2.326%
25.199910 篇2.907%
26.19988 篇2.326%
27.199710 篇2.907%
28.199616 篇4.651%
29.199510 篇2.907%
30.19948 篇2.326%
31.19936 篇1.744%
32.19922 篇0.581%
33.19916 篇1.744%
34.19902 篇0.581%
35.19896 篇1.744%
36.19882 篇0.581%
37.19873 篇0.872%
38.19863 篇0.872%
39.19853 篇0.872%
40.19832 篇0.581%
41.19812 篇0.581%
01.proc natl acad sci u s a43 篇12.500%
02.nature41 篇11.919%
03.science28 篇8.140%
04.curr biol18 篇5.233%
05.mol biol evol18 篇5.233%
06.am j hum genet11 篇3.198%
07.nucleic acids res11 篇3.198%
08.plos one10 篇2.907%
09.cell9 篇2.616%
10.nat genet9 篇2.616%
01.德国229 篇66.570%
02.美国67 篇19.477%
03.中国34 篇9.884%
04.英国28 篇8.140%
05.俄罗斯25 篇7.267%
06.瑞典18 篇5.233%
07.法国15 篇4.360%
08.日本13 篇3.779%
09.加拿大11 篇3.198%
10.西班牙11 篇3.198%
01.中国上海20 篇5.814%
02.中国北京14 篇4.070%
03.中国昆明2 篇0.581%
04.中国济南1 篇0.291%
05.中国广州1 篇0.291%
06.中国兰州市1 篇0.291%
01.Humans255 篇74.128%
02.Animals254 篇73.837%
03.Molecular Sequence Data112 篇32.558%
04.Base Sequence101 篇29.360%
05.DNA, Mitochondrial99 篇28.779%
06.Evolution, Molecular88 篇25.581%
07.Phylogeny87 篇25.291%
08.Sequence Analysis, DNA69 篇20.058%
09.Male64 篇18.605%
10.Fossils63 篇18.314%




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