Ferroptosis: lipid peroxidation, abmormal iron metabolism, hypersensitivity to free iron. 

*** iron chelation rescued mutant oligodendrocyte apoptosis, survial, and differnentiation in vitro and post-transplantation in vivo. 

O4, MBP, human-specific antibody STEM121 (red) marker, PLP, ER marker KDEL

Oligodendrocyte precursor cells (OPCs)

hiPSC--- to OPCs: Douvaras and Fossati, Nat Protoc, 2015; Wang et al (Goldman Last author), Cell Stem Cell, 2013; Nobuta, et al, Cell Stem Cell, Oct 2019