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Plant-derived natural compounds in drug discovery: The prism
郝大程 2022-9-28 23:11
Frontiers | Editorial: Plant-derived natural compounds in drug discovery: The prism perspective between plant phylogeny, chemical composition, and medicinal efficacy (frontiersin.org) Plant based natural medicine research has evolved from a long history going back to the beginning of human civ ...
281 次阅读|没有评论
[转载]感谢基金委组织评审,感谢评委专家意见,今后继续提高
郝大程 2022-9-10 01:57
感谢基金委组织评审,感谢评委专家意见,今后继续提高。 关于你的项目的同行评议意见如下: 1具体评价意见: 一、该申请项目是否面向国家需求并试图解决技术瓶颈背后的基础问题?请结合应用需求详细阐述判断理由。 人字果属植物在中国有很多特有种,具有重要的药用价值,但化学成分研究缺乏,遗传亲缘关系 ...
431 次阅读|没有评论
[转载]药物、天然化合物和污染物与肠道微生物群的多模式相互作用02
郝大程 2022-8-23 17:37
异生素-细菌相互作用机制 人类队列和动物研究表明,异生素的摄入与微生物群组成和功能之间存在许多关联。然而,只有了解潜在机制才能在健康相关场景中应用这些发现,这需要在物种和菌株水平上进行深入调查。到目前为止,已经描述了六种主要的异生素-肠道菌互作模式,以下对其进行回顾(图3,4;表1)。 图3 异生素- ...
488 次阅读|没有评论
[转载]药物、天然化合物和污染物与肠道微生物群的多模式相互作用
郝大程 2022-8-13 18:09
摘要 肠道微生物群有助于宿主生理功能的各个方面,从免疫调节到药物代谢。肠道微生物群组成的变化与各种疾病以及对药物的反应有关。因此,了解不同的生活方式和环境因素如何影响肠道微生物群组成非常重要。除了熟知的饮食因素之外,小分子药物最近被确定为微生物群组成的主要效应物。其他外源性物质(异生素),例如 ...
527 次阅读|没有评论
Impact of Drug Metabolism/Pharmacokinetics and their Relevan
郝大程 2022-8-3 21:31
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research | Bentham Science (eurekaselect.com) The representative anti-COVID-19 herbs, i.e. Poria cocos, Pogostemon, Prunus, and Glycyrrhiza plants, are commonly used in the pre ...
693 次阅读|没有评论
Evaluating potentials of species rich taxonomic groups in co
郝大程 2022-7-24 04:47
Evaluating potentials of species rich taxonomic groups in cosmetics and dermatology: Clustering and dispersion of skin efficacy of Asteraceae and Ranunculales plants on the species phylogenetic tree - PubMed (nih.gov) The medicinal properties of plants can be predicted by virtue of phylogenetic ...
803 次阅读|没有评论
Mining Therapeutic Efficacy from Treasure Chest of Biodivers
郝大程 2022-7-14 21:00
Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants | SpringerLink Ranunculales, comprising of 7 families that are rich in medicinal species frequently utilized by traditional medicine and ethnomedicine, represen ...
909 次阅读|没有评论
Distribution patterns and industry planning of commonly used
郝大程 2022-7-4 15:29
Distribution patterns and industry planning of commonly used traditional Chinese medicinal plants in China - ScienceDirect Highlights • Areas suitable for growing commonly used medicinal plants in China are the Hengduan, Nanling, Wuling, and Daba Mountains. • Southwes ...
824 次阅读|没有评论
A Global Analysis of Alternative Splicing of Dichocarpum
郝大程 2022-6-16 05:28
A Global Analysis of Alternative Splicing of Dichocarpum Medicinal Plants, Ranunculales | Bentham Science (eurekaselect.com) The multiple isoforms are often generated from a single gene via Alternative Splicing (AS) in plants, and the functional diversity of the plant genome is significantly in ...
1345 次阅读|没有评论
Chinese herbal medicines will illuminate the post-epidemic e
郝大程 2022-4-27 16:20
Chinese herbal medicines will illuminate the post-epidemic era - ScienceDirect In less than 20years since the beginning of 21th century, there have been many major outbreaks of SARS, avian influenza, H1N1 flu, Ebola virus, and COVID-19 in the world one after another. These epidemics have ...
1492 次阅读|没有评论

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