研读GATK最佳实践的研究者可能被以下描述所吸引: Prior to GATK4 this was done through hierarchical merges with a tool called CombineGVCFs. This tool is included in GATK4 for legacy purposes, but performance is far superior when using GenomicsDBImport, which produces a datastore instead of a GVCF fi ...
When should I restrict my analysis to specific intervals? This document covers the reasoning behind the use of genomic intervals. If you're looking for instructions on how to use intervals in practice, including argument details and supported formats, please see this doc . ...