Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene

Qiaoqiao Wang, Jiyu Li, Xinmiao Yang, Hefen Sun, Shuiping Gao, Hua Zhu, Jiong Wu and Wei Jin

Acta Biochim Biophys Sin 2013, 45: 179–187; doi: 10.1093/abbs/gmt001

Department of Oncology, Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China

BRCA1 is closely related to the pathogenesis of breast cancer. The activity of BRCA1 promoter is regulated by transcriptional factors. The transcription factor Nrf2 (Nuclear factor-erythroid-2p45-related factor 2) is a potent transcriptional activator and plays a central role in inducible expression of many cytoprotective genes. In this report, we found that over-expression of Nrf2 stimulated BRCA1 expression, knockdown of Nrf2 attenuated BRCA1 expression. Nrf2 also interacted with CBP and p300 to form an active transcription complex, which could bind to the ARE (antioxidant response element) site on the BRCA1 promoter and activate its transcription by inducing histone acetylation. Our finding could lead to a better understanding of the development of breast cancer.

图例: Nrf2敲除可以抑制BRCA1的表达

全文: http://abbs.oxfordjournals.org/content/45/3/179.full 

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