(参会的海内外中国人合影留念)

上午：Corrosion Session

K2: Mechanicalintegrity of magnesium-based biodegradable alloys under combined action ofstress and corrosive body fluid

Singh Raman, RK

Departmentof Mechanical and Aerospace Engineering, Department of Chemical Engineering,Monash University (Melbourne), VIC 3800, Australia

Whyare Mg alloy suspectible to SCC?

(1)Film disruption –rapiddissolution—repassivation

(20Hydrogenaccumulation and embrittlement ahead of crack-tip

CouldTWINNING accelerate SCC of Mg alloys?

SCCsusceptibility indices

Notchedspecimens need to be tested for reliable SCC data.

Circumferentialnotched tensile testing of Az91D AB 8(2012)

Al-freeMg alloys: ZX50, WZ21, WE43

Thecommon mode of SCC crack propagation is transangular

Thereis great needs of developing SCC and CF data for Mg alloys for biomedicalapplications

O8. Bending strengthand crack propagation in cast Mg10Gd influenced by corrosion

Maier P, Mendis CL,Tober G, Briesemeister J, Minciel E, Hort N

Universityof Applied Sciences Stralsund, Stralsund, Germany

Mg-10Gd

Prebendingplates: contour to fit the bone surface, straight plate to curves bone

Samples110X20X4mm

Span=90mm

1mm/min

Bendingincrease strength(stability)

Bendingdecreases fracture toughness, so “cold working” should be avoided.

O9. Effects of grainsize on the corrosion resistance of Mg-Zn-Ca Alloy

Liu D, Liu L, Liu Y,Song R, Chen M

Schoolof Materials Science and Engineering, Tianjin University of Technology, Tianjin300384, China

Corrosionscience 52(2010) 589-594

Copperwedge shape mould to reach different grain size

Theaddition of Ca-P ceramic can act as grain refiner. Further ECAP will furtherimprove the corrosion resistance.

O10. Biodegradationbehaviour of magnesium alloy under flow-induced shear stress

Wang J, Shanov V, XuZG, Jang Y, Giri V, Collins B, Sankar J, Huang N, Yun Y

EngineeringResearch Center for Revolutionizing Metallic Biomaterials, North Carolina A& T State University, NC, USA

Computationalanalysis on Flow-induced shear stress

Mg-5Zn-0.3Ca,AZ31

Insitu and real-time electrochemical monitoring of the corrosion under FISS

O11. Investigation ofcoated magnesium alloys by IR, Raman, X-ray and Mass spectrometry

Vano-Herrera K,Zimmermann F, Stekker M, Vogt C

LeibnizUniversity Hannover, Institute for Inorganic Chemistry, Germany

Degradationof protective layers polymers on stent

Micro-Raman

Sensitivity(smallspots for high x-y resolution)

Correctionmethods for instrument parameters

Matrix-matchedcalibration

Methods:

Jointmelting of both polymers

Dryingof solution

Micro-XRFfor degradation products ex vivo

40KV image size 4.7X3.6mm

Resolution10 micrometer

Micro-PIXEdetect on biodegradation products

2.25MeVprotons

Resolution1 micrometer,

NdL, coronary artery, 4 weeks

Surveyscan

Histomorphologicalanalysis?

用 PIXE 分析支架的切片，利用元素谱像，更精确测定支架内的内膜厚度，比histology。

还可以测量Degree of calcification

LADand LCx

Needlein a haystack

Whybackground values are important?

Letassume to put 1 g Mg implant in a 1 Kg rat

1g/Kg

Letassume the alloy contains 10% of an alloying elements

0.1g/Kg(100ppm)

Muchmore realistic 1mg og Mg implant in a kg rat

1mg/kgand o.1mg/kg (100ppb)

Analyticalchallenges

Valuesessential to determine enrichment processes in organs and tissue afterimplantation of alloys

Valuesin biological samples from ppm (ug/g) to sub-pppb (fg/g) levels

Severalanalyitical techniguqes

ICP-OES,ICP-MAS clean room conditions

Complexcleaning routine of vials and tools required (sub-boiled acids, ultra-purewater, special materials for vials)

SOP17. Electrochemicaldetection of magnesium ions using magnesium biosensor

Natasha S, Malon RSP,Wicaksono DHB, Corcoles EP, Hermawan H

Facultyof Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM),Malaysia

Todevelop a real time

原理：Kinase enzyme

Cotton-basedanalytical device

SOP18. Effect ofstress on the corrosion behaviour of magnesium wire in m-SBF

Zhang S, Li X, Wu H,Zhao C, Liu J, Zhang Y, Zhang X

Schoolof Materials Science and Engineering, Shanghai Jiao Tong University, China

0.3mmin diameter

Surgicalstaple nail in U-shape and after use it becomes B-shape

0MPa—20MPa: 550h—250h

SOP19. Nanorod-shapedhydroxyapatite formed on pure magnesium by Micro-arc oxidation and hydrothermaltreatment

Han Y, Li B

State-keyLab for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an710049, China

()

源于他们在Ti上的工作

SOP20.Inhibitor-loaded chitosan coatings on the microarc oxidized Mg-1Ca alloy

Jia ZJ, Li M, Liu Q,Xu XC, Cheng Y, Zheng YF, Xi TF, Wei SC

Centerfor Biomedical Materials and Tissue Engineering, Academy for AdvancedInterdisciplinary Studies, Peking University, China

MAO-Mg-Ca后甩上壳聚糖

SOP21. In vitrobiocorrosion behavior of Mg-Nd-Zn-Zr alloy evaluated by different methods

Zhang X, Yuan G, WangZ, Xue Y

Schoolof Materials Science and Engineering, Nanjing Institute of Technology, China

T4,E, EA 三种处理

SOP22. Corrosionbehaviour of Mg-aCa-bY extrusions in simulated body fluid

Yim CD, Woo SK, KimYM, You BS

Light Metal Division, Korea Institute of MaterialsScience, South Korea

SOP23. AbsorbableMg-ND composite and Zn alloy for surgical implant application

Zhou J, Gong H, Yao D

MechanicalEngineering and Mechanics Department, Drexel University, USA

Highenergy ultrasonication assisted mixing process

NanoCeO2+ Mg 复合材料

Zn-1Mg,weight loss rate is low, but implant can lose intergrity in weeks

SOP24. Hydroxyapatiteand octacalcium phosphate coating of bioabsorbable Mg-Ca alloys by a novelchemical solution deposition method

Hiromoto S, Hanada K,Matsuzaki K

BiomaterialsUnit, National Institute

HAand OCP coating on Mg-Ca by chemical solution deposition methods at pH value6.1 and 8.9

H2evolution rate 0.01-0.03 mlNaN2/day

下午报告会：

in vitro session

K3: In vitrostrategies to mimic in vivo events after osseous implantation

Luthringer BJC, Wu L,Costantino M, Burmester A, Schiling AF, Feyerabend F, Wilumeit R

Departmentfor Structural Research on Macromolecules, Institute of Materials Research,Helmholtz-Centre Geesthacht, Geesthacht, Germany

Whichare the correct environmental parameters, (mechanical, corrosive, cytotoxicity,genotoxicity)

Animalexperimental  ---Problematic

Literatures:Primary OB, MG63, SAOA2 U2OS MC3T3, are all cell types suitable for Mg tests?

Areother cell types needed to study Mg degradation?

GUT2008; 57:684-694

Osteoblastsas cell model for Mg studies

OsmolalityDMEM 0.319

Cellsize of adherent cells 受镁离子影响

Geneexpression qualitative RT-PCR受镁离子影响

Useprimary cells whenever possible

Itmatters in which form the Mg is present

Howare Osteoclast influenced?

Cellmodel: peripheral blood mononuclear cells(PBMC)

Numberof OCs seems to be reduced

OB/OCco-culture to test Mg

RatioOC/OB: 100:1 without RANKL and MCSF

Firstresults with Macrophages

Establishmentof a suitable model: cell line U937

Co-culturewith OB in the future

Thecorrect octeoblast model : primary cells

AlsoOCs are influenced may be even better model

OB/OCco-culture give different results---See if the degradation is different

O12. Influence ofstrontium concentration on in vitro corrosion property and cytocompatiblity ofternary Mg-Zn-Sr alloys

Tie D, Guan RG, Cui T,Wu LL, Song LL, Qin HM

NortheasternUniversity, Shenyang, China

4个成分

植入动物16周后，全部降解。4mm/year是铸态

O13. In vitro studieson Mg-Ge(-Ca, Zn) alloy system newly-developed for potential biomedicalapplications

Zheng YF, Zhou WR,Ruan L

StateKey Laboratory for Turbulence and Complex System and Department of MaterialsScience and Engineering, College of Engineering, Peking University, China

O14. Corrosion of zincin PBS, Ringer solution, blood plasma and whole blood

Törne K, WeissenriederAN, Weissenrieder J

MaterialsPhysics, KTH Royal Institute of Technology, Kista, Sweden

2011年开始，和ST.Jude Medical合作

Plasma270micrometer /y;

J.Electrochem Soc. 1988, 135:332-339

ElectrochimActa 2009 54:1204-1209

PBSZn2(PO4)2.4H2O

RingerZn5(CO3)2…

Corrosionresistance 在不同溶液不同

以下为5分钟的短报告

O15. Cytotoxicityevaluation of Mg-Sn-Mn alloy on mouse fibroblasts

Yang L, Zhen Z, Lai C,Xi TF

Centerfor Biomedical Materials and Tissue Engineering, Academy for AdvancedInterdisciplinary Studies, Peking University, Beijing, China

蛋白质组学研究，我代讲

SOP25.Degradation and cytocompatibility of magnesium alloys formedical applications –an introduction to methods and observations

LiuH

InterdisciplinaryMaterials Science and Engineering Program, Bourns College of Engineering,University of California, Riverside, CA. USA

ACL界面螺钉

体外研究：AZ31 Pure Mg比mg-4Y降解慢，

SOP26.Preincubation increases in vitro cell adhesion to magnesium and its alloys

FeyerabendF, Mohring A, Wilumeit R

Helmholtz-ZentrumGeesthacht, Geesthacht, Germany

Directapplication of cells on Mg materials often is not working

Whynot try a preincubation step?

Woundhealing is time consuming

Mg10Gd1Ndextruded

Increasein preincubation time increase cell adhesion and reduce the amount of dead cells

Canthis be related to the corrosion layer? YES

Na7Mg13Nd(PO4)12

SOP27.Assessment of cellular effects in the vicinity of Mg, AZ31 and ZEK100 alloys

GrilloCA, Alvarez F, Muller WD, Fernandez Lorenzo de Mele M

Charité Universitaetsmedizin Berlin, Germany

SOP28. Bioresorbablemetallic interference screws for anterior cruciate ligament reconstruction – anevaluation of mechanical and degradation properties

Patel T, Iskandar ME,Liu H

Interdisciplinary Materials Science and EngineeringProgram, Bourns College of Engineering, University of California, Riverside,CA. USA

SOP29. Effect ofproteins and cells on degradation behaviour of Mg-Nd-Zn-Zr alloy

Zhang J, Kong N, LiHY, Yuan GY

Schoolof Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

用了FBS=fetal bovine serum, ECGS=endotheialcell growth supplement HUVEC

Proteindecrease Mg alloy degradation rate

Cellsincrease Mg alloy degradation rate

SOP30.Characterization of hydroxyapatite containing micro-arc oxidation coating onZK60 magnesium alloy

Lin X, Yang XM, TanLL, Zhang Y, Yang K

Instituteof Metal Research, Chinese Academy of Sciences, Shenyang, China

HA涂层

SOP31. The degradationrate and cytocompatibility of Zn-3Mg alloy

Dambatta MS, Mrni NS,Sudin I, Hermawan H

Facultyof Mechanical Engineering, Universiti Teknologi Malaysia (UTM), Malaysia

Zn《 MgStrength； corrosion resistance Zn>Mg

COMETASSAY it does not cause DNA damage to NHOst

0.75mg/mlis the maximum for Zn-3Mg which is cytocompatible

SOP32. In vitrodegradation and biocompatibility of ZK60 magnesium alloy with Sr-containingmicro-arc oxidation coating

Lin X, Yang XM, TanLL, Zhang Y, Yang K

Instituteof Metal Research, Chinese Academy of Sciences, Shenyang, China

P、Sr-P涂层

SOP33. Anticorrosionand cytocompatibility of biodegradable polylactide/MgO composite coating onAZ31 alloy

Tian P, Liu XY

Shanghai Institute of Ceramics, Chinese Academy ofSciences, Shanghai 200050, China

SOP34. The interactionof fibroblast cells on the surface of porous iron

Daud NM, Hermawan H

Faculty of Biosciences and Medical Engineering,University Teknologi Malaysia (UTM), Malaysia

BIOMETAL2014讨论

What, Where, When

Isolateplace with attendees occupying the entire hotel

Keywords:learning, sharing, discussing, networking, exchanging, meeting

Logistic:healthy, safeness, cleanness, affordable cost, all included registeration rate

Eco-responsibleand unconventional

2009Berlin 4 companies/2 sponsors

2010-Maratea7 companies/4 sponsors

2011Quebec City 10 companies/6 sponsors

2012-Maratea11 companies/7 sponsors

2013-Umang island, Indonesia, ASIA-PACIFIC edition 5 companies/2 sponsors

选择一：Maratea

Advantages:hotel will be ours

Safeness,not extreme, accessable

28Aug- 2 Sept

选择二：Malta

Inconvenient/advantage

Dispersedin hotel, date/new location

IntercontinentalHotel St Gillians, 4*, Malta

可以从Frankfurt转机

3-8Nov or 10-15 Nov