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这是氢气生物学领域为数不多的临床研究报道,过去只有关于糖尿病治疗的3篇报道。本报道扩展了临床效果报道的范围。值得鼓励。
这是《气体医学研究》第三期 刚发表的论文,是来自韩国的研究,采用饮用Friender公司的氢水棒制备的氢气水,研究给肝癌患者放射治疗后的生活质量。众所周知,肝癌的最有意义的手段是预防,最佳临床手段是早期发现,及时手术,如果无法手术,放射和化疗就成为最后一项选择。但是放射治疗对肿瘤具有明确的杀伤和治疗效果,但是放射治疗本身对患者也会造成伤害,严重影响患者的生活质量。本研究发现,给患者在放射治疗期间饮用一定量的氢气水,可以有效改善患者生活质量,这一消息无疑给这类患者带来一种新的选择,可以在不影响其他治疗手段的同时采用这个手段,提高生活质量。
研究背景,肿瘤患者接受放射治疗常会感觉到疲劳,并明显影响生活质量。放射治疗的许多副作用都与放射线引起的氧化应激和炎症反应释放大量活性氧有密切关系。氢气能作为治疗性气体,具有抗氧化和降低炎症反应的作用。本研究观察通过饮水供应氢气是否能提高放射治疗后患者的生活质量。
研究方法,对49例接受放射治疗的恶性肝癌患者,采用随机安慰剂对照方法。氢气水采用金属镁与水反应制备,氢气水氢气浓度为0.55-0.65 mM。采用肿瘤研究与治疗欧洲组织QLQ-C30量表韩国版作为生活质量的评价方法。氧化损伤指标为患者外周血自由基代谢产物和抗氧化能力。
结果:饮用6周氢气水能降低血液中活性氧代谢产物,维持血液抗氧化能力。在放射治疗期间,与对照组比较,饮用氢气水的患者生活质量评分显著提高。两组患者的肿瘤本身的反应未发现不同。
结论:日常饮用富氢气水是可提高肿瘤患者放射治疗期间生活质量的一种新的治疗措施。氢气水在降低放射治疗引起的氧化应激的同时不影响肿瘤的放射治疗效果。
本人评价:氢气能提高放射治疗患者的生活质量,是非常令人高兴的发现,氢气使用方便,副作用小。我个人有一些相关资料,有一些恶性肿瘤患者晚期因为身体问题无法承受放射和化学治疗,氢气治疗一段时间后,能接受放射和化学治疗的情况。当然这些不能作为科学证据。本研究至少从严密的临床研究角度,给我们提供了一个比较客观的证据。当然研究的患者数量少,只能是初步的结论,最终的结论需要大量患者数据的分析。
研究中让人不放心的一个问题是,放射治疗肿瘤的机制也是通过自由基,氢气可以对抗自由基引起的氧化损伤,那么对肿瘤细胞本身也应该具有保护作用,从这个角度考虑,氢气也许具有降低放射治疗效果的作用。当然,现在的放射治疗方法对采用局部照射,一方面能减少全身副作用,另一方面能提高对肿瘤的杀伤效果,氢气全身使用,对局部的“大剂量”放射线可能不具有防护效果。这个问题仍值得探讨。我在审阅该论文的时候也提出这个问题。
Short communication
Effects of Drinking Hydrogen-Rich Water on the Quality of Life of Patients Treated with Radiotherapy for Liver Tumors
Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda and Atsunori Nakao
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Medical Gas Research 2011, 1:11 doi:10.1186/2045-9912-1-11
Published: 7 June 2011
Background
Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties and reduces inflammation in tissues. This study examined whether hydrogen administration, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy.
Methods
A randomized, placebo-controlled study was performed to evaluate the effects of hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced, by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancers QLQ-C30 instrument was used to evaluate a global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed.
Results
The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water as compared with patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups.
Conclusions
Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.
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