科学家发现导致乳腺癌耐药新标志物

 

Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer

 

知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=1312

 

Start A-Literature C-Literature B-list Filter Literature   检索策略：

A-query: CUEDC2 C-query: breast cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 2 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 1312 and can be accessed from the start page after you leave this session. There are 20 terms on the current B-list (8 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

知识发现结果：

job id # 1312 started Tue May 17 02:25:20 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
1312 Search ARROWSMITH A
A_query_raw: CUEDC2Tue May 17 02:25:31 2011

A query = CUEDC2 started Tue May 17 02:25:31 2011
A query resulted in 4 titles
1312 Search ARROWSMITH C
C_query_raw: breast cancer Tue May 17 02:26:45 2011

C: breast cancer 228918

A: pubmed_query_A 4

AC: ( CUEDC2 ) AND ( breast cancer ) 2

C query = breast cancer started Tue May 17 02:26:46 2011
C query resulted in 50000 titles
A AND C query resulted in 2 titles
20 B-terms ready on Tue May 17 02:29:29 2011

密切相关知识概念（文献中隐含的知识概念）：以下关键词与炎症调控分子CUEDC2与乳腺癌的关系，按概念的相关性排列。科研人员可以分析研究这些知识概念的研究论文，从中得到科学启发和认识。

B-list on Tue May 17 02:42:04 2011
1 ikk
2 lncap
3 prostate cancer
4 gene expression
5 prostate
6 kinase
7 recruitment
8 atla
9 recurrent
10 expression associated
11 gene
12 cancer
13 progression
14 expression
15 gene expression associated
16 castration
17 phosphatase
18 deactivation
19 vivo
20 associated

研究课题：

CUEDC2

ikk

breast cancer

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature B-term BC literature CUEDC2 ikk breast cancer 1: Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. 2008 Add to clipboard 1: Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. 2011 Add to clipboard 2: Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. 2010 Add to clipboard 3: Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway. 2009 Add to clipboard 4: Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. 2008 Add to clipboard 5: IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. 2007 Add to clipboard 6: Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin. 2007 Add to clipboard