从2007年后，经过三年的发展，氢气生物医学的研究逐渐成为一个热点，目前发表的论文已经接近80篇，主要是因为氢气对许多疾病具有确定治疗效果，氢气本身是没有任何毒性的天然物质，氢气也属于机体内源性的物质，可能就属于机体正常的防御体系。

    从氢气也属于机体内源性的物质这个角度出发，长海医院烧伤科夏照帆教授提出了一种新观念：氢气复苏。所谓氢气复苏是指在疾病情况下，作为正常防御体系的氢气水平无法满足机体防御损伤的要求，需要额外补充外源性氢气以实现治疗疾病目的的方式。以该概念为中心，他们发表了一篇综述，被临床实验药理和生理学杂志接受并在线发表。

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2011.05479.x/abstract

Hydrogen Resuscitation, a New Cytoprotective Approach

Xing-Feng ZHENG1, Xue-Jun SUN2, Zhao-Fan XIA1

DOI: 10.1111/j.1440-1681.2011.05479.x

Summary

Hydrogen is a colourless, odourless, tasteless and flammable gas. Hydrogen is considered a physiologically inert gas and is often used in deep-sea diving medicine. In mammals, endogenous hydrogen is produced as a result of the fermentation of non-digestible carbohydrates by intestinal bacteria and it is absorbed into the systemic circulation.

Recent evidence indicates that hydrogen is a potent anti-oxidative, anti-apoptotic and anti-inflammatory agent and so may have potential medical application. The present review evaluates the concept of ‘hydrogen resuscitation’, based on knowledge that hydrogen treatment effectively protects cells, tissues and organs against oxidative injury and help them recover from dysfunction.

Hydrogen therapy can be delivered by inhalation, the administration of hydrogen-enriched fluid or by approaches that affect endogenous hydrogen production.

Studies have shown that hydrogen resuscitation has cytoprotective effects in different cell types and disease models including ischemia-reperfusion injury, inflammation, toxicity, trauma, metabolic disease, etc. The underlying mechanism may be the selective elimination of hydroxyl radicals, although other mechanisms may also be involved (e.g. hydrogen functioning as a gaseous signaling molecule).

Hydrogen resuscitation may have several potential advantages over current pharmacological therapies for the oxidative injuries. However, more work is needed to identify the precise mechanism underlying the actions of hydrogen and to validate its therapeutic potential in the clinical setting.