2: Low p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma. 2003
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2: Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. 2010
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3: USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. 2009
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4: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. 2009
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5: TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest. 2009
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6: Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. 2009
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7: Overexpression of adenovirus-mediated p27kip1 lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth. 2009
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8: Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells. 2009
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9: Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer. 2009
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10: Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer. 2008
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11: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. 2008
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12: EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein. 2008
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13: MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells. 2008
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14: Expression of p27kip1 and Skp2 in the adult spinal cord following sciatic nerve injury. 2007
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15: Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. 2007
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16: Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. 2007
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17: p27kip1 overexpression promotes paclitaxel-induced apoptosis in pRb-defective SaOs-2 cells. 2006
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18: HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells. 2006
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19: Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: definition of an arterial smooth muscle PTHrP/p27kip1 pathway. 2006
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20: Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer. 2006
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21: HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. 2005
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22: Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins. 2005
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23: Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. 2005
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24: BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells. 2005
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25: Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. 2005
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26: Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. 2005
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27: Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells. 2004
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28: Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins. 2004
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29: The prognostic and therapeutic relevance of p27kip1 in Ewing's family tumors. 2004
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30: Adenovirus expressing mutant p27kip1 enhanced apoptosis against cholangiocarcinoma than adenovirus-p27kip1 wild type. 2004
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31: P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori. 2004
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32: Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells. 2004
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33: Facilitation of proteasomal degradation of p27Kip1 by N-terminal cleavage and their sequence requirements. 2004
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34: NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner. 2004
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35: PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression. 2003
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36: The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. 2003
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37: Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. 2003
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38: Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. 2003
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39: The role of p27Kip1 in proteasome inhibitor induced apoptosis. 2003
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40: P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. 2003
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41: Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1. 2002
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42: Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1. 2001
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43: IFNalpha 2b induces apoptosis and proteasome-mediated degradation of p27Kip1 in a human lung cancer cell line. 2001
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44: CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. 2001
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45: Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1. 2001
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46: The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells. 2001
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47: A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. 2001
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48: Dynamic changes in p27kip1 variant expression in activated lymphocytes. 2001
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49: Regulation of p27KIP1 in Epstein-Barr virus-immortalized lymphoblastoid cell lines involves non-apoptotic caspase cleavage. 2001
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50: p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation. 2000
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51: p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. 2000
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52: A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. 2000
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53: Differentiation-associated expression and intracellular localization of cyclin-dependent kinase inhibitor p27KIP1 and c-Jun co-activator JAB1 in neuroblastoma. 2000
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54: BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway. 2000
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55: p27KIP1: androgen regulation and prognostic significance in prostate cancer. 2000
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56: p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. 1999
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57: Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. 1999
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58: Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. 1999
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59: Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma. 1998
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