氢气对前庭毛细胞氧化损伤的保护作用

我前几天写了一篇文章，提出科研可以进行简单复制，虽然有一些惴惴不安，觉得提出了一个不太好的建议。但科研领域确实存在不少这样的情况，而且这种看上去简单复制的研究手段仍具有一定价值。

一年前日本学者研究过氢气对耳蜗听毛细胞氧化损伤具有保护作用，当时我提出应该进行耳聋的保护研究，后来日本学者又证明氢气可以保护噪声性耳聋。当时我确实没有想到，也可以对另外一个毛细胞具有同样的保护作用，今天看到这个文章，才恍然。氢气对一种毛细胞具有保护作用，对另一种毛细胞显然也应该具有保护作用，我当时怎么没有想到。主要原因是我对耳朵内这两类毛细胞的背景不太了解，甚至我忘记了在前庭内也存在毛细胞这样一个知识。回想起学习神经解剖时，对平衡觉和听觉的区别是很好地思考过。看来仍没有全面理解。不过主要是我多年来没有了解过相关知识才出现这样的判断失误。

这个研究采用的研究模式与研究听毛细胞的简直一样，没有特别值得说的。不过显然会有人会考虑在体的平衡觉损伤，甚至人类的前庭损伤进行实验性治疗。估计1年内会有这样简单复制的论文出现。

 

Acta Otolaryngol Suppl. 2010 Nov;(563):95-100.

Hydrogen protects vestibular hair cells from free radicals.pdf

Taura A, Kikkawa YS, Nakagawa T, Ito J.

Department of Otolaryngology-Head and Neck Surgery, Kyoto University, Kyoto, Japan.

Abstract

CONCLUSION: Hydrogen gas effectively protected against the morphological and functional vestibular hair cell damage by reactive oxygen species (ROS).OBJECTIVE: ROS are generally produced by oxidative stress. In the inner ear, ROS levels increase as a result of noise trauma and ototoxic drugs and induce damage. It is thus important to control ROS levels in the inner ear. The protective effects of hydrogen gas in cochlear hair cells have been reported previously.METHODS: This study examined the effects of hydrogen gas on mouse vestibular hair cell damage by ROS using antimycin A.RESULTS: In the group *exposed to hydrogen gas, vestibular hair cells were morphologically well preserved and their mechano-electrical transduction activities were relatively well maintained when compared with controls. Hydroxyphenyl fluorescein (HPF) fluorescence in vestibular tissue was also reduced by hydrogen gas.

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