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Ralph M. Steinman的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测）
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美国洛克菲勒大学 细胞生理学和免疫学实验室 教授兼高级医师 Ralph M. Steinman
获奖原因
因发现作为关键免疫应答调节物的树突状细胞而获奖
rockefeller.edu [PDF]J Banchereau, RM Steinman… - Nature, 1998 - rockefeller.edu
Jacques Banchereau & Ralph M. Steinman ........................................................................................
......................................................................................................... ... ... Immunology has long been focused
on antigens and lymphocytes, but the mere presence of these two parties does not ...
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Jacques Banchereau & Ralph M. Steinman ........................................................................................
......................................................................................................... ... ... Immunology has long been focused
on antigens and lymphocytes, but the mere presence of these two parties does not ...
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rupress.org [HTML]G Schuler, RM Steinman - The Journal of experimental medicine, 1997 - jem.rupress.org
Animal experiments as well as clinical experience, notably in melanoma, indicate that the immune
system can recognize and kill tumor cells. In particular, CTLs recognize MHC class I–peptide
complexes on the tumor cell surface, and the peptides are derived from nonmutated or ...
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Animal experiments as well as clinical experience, notably in melanoma, indicate that the immune
system can recognize and kill tumor cells. In particular, CTLs recognize MHC class I–peptide
complexes on the tumor cell surface, and the peptides are derived from nonmutated or ...
Cited by 375 - Related articles - BL Direct - All 9 versions
nih.gov [HTML]… Dhodapkar, RM Steinman, M Sapp, H … - Journal of Clinical …, 1999 - Am Soc Clin Investig
Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity
in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously
with a control injection of autologous monocyte-derived, mature DCs, followed 4–6 weeks ...
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Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity
in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously
with a control injection of autologous monocyte-derived, mature DCs, followed 4–6 weeks ...
Cited by 354 - Related articles - BL Direct - All 13 versions
rockefeller.edu [PDF]RM Steinman, D Hawiger, MC Nussenzweig - 2003 - Annual Reviews
... both subsets can capture virus like particles (125) and soluble proteins (K. Liu, B. Bonifaz, K.
Inaba & RM Steinman, unpublished observations). ... mice prior to deletion and then stimulated
in culture, they exhibited changes consistent with the development of immunity rather than ...
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... both subsets can capture virus like particles (125) and soluble proteins (K. Liu, B. Bonifaz, K.
Inaba & RM Steinman, unpublished observations). ... mice prior to deletion and then stimulated
in culture, they exhibited changes consistent with the development of immunity rather than ...
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rupress.org [HTML]… Dhodapkar, RM Steinman, J Krasovsky, C … - The Journal of …, 2001 - jem.rupress.org
... Footnotes. Submitted: 13 September 2000; Revision requested 27 October 2000; Accepted: 7
November 2000. Previous Section. References. ↵: Banchereau, J.,; RMSteinman. (1998) Dendritic
cells and the control of immunity. Nature. 392:245–252, pmid:9521319. ...
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... Footnotes. Submitted: 13 September 2000; Revision requested 27 October 2000; Accepted: 7
November 2000. Previous Section. References. ↵: Banchereau, J.,; RMSteinman. (1998) Dendritic
cells and the control of immunity. Nature. 392:245–252, pmid:9521319. ...
Cited by 1028 - Related articles - BL Direct - All 7 versions
rupress.org [HTML]… Shimizu, C Smith, L Bonifaz, RM Steinman - The Journal of …, 2003 - jem.rupress.org
The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate
immunity. We pursued this concept in situ by studying the adjuvant action of α-galactosylceramide
(αGalCer) in mice. A single iv injection of glycolipid induced the full maturation of splenic ...
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The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate
immunity. We pursued this concept in situ by studying the adjuvant action of α-galactosylceramide
(αGalCer) in mice. A single iv injection of glycolipid induced the full maturation of splenic ...
Cited by 320 - Related articles - BL Direct - All 7 versions
rockefeller.edu [PDF]RM Steinman - Annual review of immunology, 1991 - Annual Reviews
... 272 STEINMAN such as the acquisition of antigens in tissues, the migration to lymphoid organs,
and the identification and activation of antigen ... share features of structure and function, the most
notable being the ability to capture antigens and initiate T cell mediated immunity. ...
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... 272 STEINMAN such as the acquisition of antigens in tissues, the migration to lymphoid organs,
and the identification and activation of antigen ... share features of structure and function, the most
notable being the ability to capture antigens and initiate T cell mediated immunity. ...
Cited by 3645 - Related articles - All 7 versions
rupress.org [HTML]… Saternus, Y Kimura, K Inaba, RM Steinman - The Journal of …, 2002 - jem.rupress.org
Peripheral immune tolerance is believed to be induced by the processing and presentation of
self-tissues that die during physiologic tissue turnover. To examine the mechanism that mediates
tolerance, we injected mice with dying syngeneic TAP −/− splenocytes loaded with small ...
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Peripheral immune tolerance is believed to be induced by the processing and presentation of
self-tissues that die during physiologic tissue turnover. To examine the mechanism that mediates
tolerance, we injected mice with dying syngeneic TAP −/− splenocytes loaded with small ...
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rupress.org [HTML]… K Liu, C Smith, AJ Bonito, RM Steinman - The Journal of …, 2004 - jem.rupress.org
Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered
proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied
α-galactosylceramide. This glycolipid activates innate Vα14 + natural killer T cell (NKT) ...
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Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered
proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied
α-galactosylceramide. This glycolipid activates innate Vα14 + natural killer T cell (NKT) ...
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Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion
Vaccinia virus employs multiple mechanisms to evade the immune system, yet is highly
immunogenic. We studied the interaction between vaccinia and human dendritic cells (DCs),
potent APCs. DCs develop from precursor cells in two stages: an immature stage in which ...
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G Schuler, B Schuler-Thurner, RM Steinman - Current opinion in …, 2003 - Elsevier
... Author , * , Beatrice Schuler-Thurner E-mail The Corresponding Author , * and Ralph M Steinman
E-mail ... immunogenicity trials (ie addressing a given variable in two ways and using immune
monitoring to ... 1. RM Dallal and MT Lotze, The dendritic cell and human cancer vaccines ...
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... Author , * , Beatrice Schuler-Thurner E-mail The Corresponding Author , * and Ralph M Steinman
E-mail ... immunogenicity trials (ie addressing a given variable in two ways and using immune
monitoring to ... 1. RM Dallal and MT Lotze, The dendritic cell and human cancer vaccines ...
Cited by 423 - Related articles - All 4 versions
rupress.org [HTML]… Den Driesch, EB Bröcker, RM Steinman, A … - The Journal of …, 1999 - jem.rupress.org
... Schuler, G.,; RMSteinman. (1997) Dendritic cells as adjuvants for immune-mediated resistance
to tumors. J. Exp. ... Am. 4Suppl.1998S14pmid:9619263. ↵: Banchereau, J.,; RMSteinman. (1998)
Dendritic cells and the control of immunity. Nature. 393:245–252, pmid:9521319. ...
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... Schuler, G.,; RMSteinman. (1997) Dendritic cells as adjuvants for immune-mediated resistance
to tumors. J. Exp. ... Am. 4Suppl.1998S14pmid:9619263. ↵: Banchereau, J.,; RMSteinman. (1998)
Dendritic cells and the control of immunity. Nature. 393:245–252, pmid:9521319. ...
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pnas.org [HTML]RM Steinman, MC … - Proceedings of the …, 2002 - National Acad Sciences
... Contributed by Ralph Marvin Steinman. Next Section. Abstract. ... In the steady state, meaning
in the absence of acute infection and inflammation, DCs are in an immature state and not fully
differentiated to carry out their known roles as inducers of immunity. ...
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... Contributed by Ralph Marvin Steinman. Next Section. Abstract. ... In the steady state, meaning
in the absence of acute infection and inflammation, DCs are in an immature state and not fully
differentiated to carry out their known roles as inducers of immunity. ...
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[HTML] Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
... Submitted: 26 June 2001; Revision requested 2 August 2001; Accepted: 10 August 2001.
Previous Section. References. ↵: Banchereau, J.,; RMSteinman. (1998) Dendritic cells
and the control of immunity. Nature. 392:245–252, pmid:9521319. ...
Cited by 943 - Related articles - BL Direct - All 9 versions
rockefeller.edu [PDF]JG Tew, GJ Thorbecke, RM Steinman - J. Reticuloendothel. Soc, 1982 - rockefeller.edu
372 Tew, Thorbecke, and Steinman The names and abbreviations we recommend for the
D-cells are listed in Table 1 The cardinal features of each category of D-cells are indicated in
the column across from the name. As indicated in the footnotes, a number of names have ...
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372 Tew, Thorbecke, and Steinman The names and abbreviations we recommend for the
D-cells are listed in Table 1 The cardinal features of each category of D-cells are indicated in
the column across from the name. As indicated in the footnotes, a number of names have ...
Cited by 184 - Related articles - All 3 versions
rupress.org [HTML]RM Steinman, S Turley, I Mellman, K … - The Journal of …, 2000 - jem.rupress.org
... Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses
and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med.
188:2019–2031, pmid:9841916. Abstract/FREE Full Text. ↵: O'Doherty, U.,; RMSteinman,; M. ...
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... Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses
and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med.
188:2019–2031, pmid:9841916. Abstract/FREE Full Text. ↵: O'Doherty, U.,; RMSteinman,; M. ...
Cited by 851 - Related articles - BL Direct - All 8 versions
GJ Randolph, K Inaba, DF Robbiani, RM Steinman, WA … - Immunity, 1999 - Elsevier
We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed
subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became
microsphere + macrophages, which remained in subcutaneous tissue. However, about ...
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We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed
subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became
microsphere + macrophages, which remained in subcutaneous tissue. However, about ...
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[HTML] Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
... K. Inaba and RM Steinman share senior authorship. ... 2001. Immunologic tolerance maintained
by CD25 + CD4 + regulatory T cells: their common role in controlling autoimmunity, tumor
immunity, and transplantation tolerance. Immunol. Rev. 182:18–32. ...
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rupress.org [HTML]… M Rivera, MC Nussenzweig, RM Steinman - The Journal of …, 2002 - jem.rupress.org
... and RM Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as
identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753–1771. Abstract/FREE
Full Text. ↵ Heath, WR, and FR Carbone. 2001. Cross-presentation in viral immunity and ...
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... and RM Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as
identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753–1771. Abstract/FREE
Full Text. ↵ Heath, WR, and FR Carbone. 2001. Cross-presentation in viral immunity and ...
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rupress.org [PDF]SL Koide, K Inaba, RM Steinman - Journal of Experimental …, 1987 - jem.rupress.org
Evidence that soluble factors are important in T cell mitogenesis began with experiments in which
leukocyte-conditioned media enhanced growth in the presence of lectin (1, 2). Two factors were
identified in these media (3): IL-1, a macrophage product originally termed lymphocyte ...
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Evidence that soluble factors are important in T cell mitogenesis began with experiments in which
leukocyte-conditioned media enhanced growth in the presence of lectin (1, 2). Two factors were
identified in these media (3): IL-1, a macrophage product originally termed lymphocyte ...
Cited by 156 - Related articles - All 4 versions
RM Steinman, D Hawiger, K Liu, L … - Annals of the New …, 2003 - interscience.wiley.com
... Med. 182: 261–266. 9. DADAGLIO, G., CA NELSON, MB DECK, et al. 1997. Characterization
and quantita- tion of peptide-MHC complexes produced from hen egg lysozyme using a mono-
clonal antibody. Immunity 6: 727–738. 10. STEINMAN, RM & MC NUSSENZWEIG. 2002. ...
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... Med. 182: 261–266. 9. DADAGLIO, G., CA NELSON, MB DECK, et al. 1997. Characterization
and quantita- tion of peptide-MHC complexes produced from hen egg lysozyme using a mono-
clonal antibody. Immunity 6: 727–738. 10. STEINMAN, RM & MC NUSSENZWEIG. 2002. ...
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rupress.org [HTML]… Tsang, L Moretta, G Melioli, RM Steinman, … - The Journal of …, 2002 - jem.rupress.org
... Submitted: 2 July 2001; Accepted: 10 December 2001; Revision received 26 November
2001. Previous Section. References. ↵ Banchereau, J., and RM Steinman. 1998.
Dendritic cells and the control of immunity. Nature. 392:245–252. ...
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... Submitted: 2 July 2001; Accepted: 10 December 2001; Revision received 26 November
2001. Previous Section. References. ↵ Banchereau, J., and RM Steinman. 1998.
Dendritic cells and the control of immunity. Nature. 392:245–252. ...
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RM Steinman, M Pack, K Inaba - Immunological reviews, 1997 - interscience.wiley.com
... Abbot A. Tew JG. The rolllcular dendritic cell: long term antigen retention during immunity, Immunol
Rev 1980;S3:29-S9, Liu YJ. Grouard G. de Bouteiller O, Bantliereau ), FoUicular dendritic cells and
germinal centers, Im Rev Cytology 1996;166:139-179. Steinman RM. ...
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... Abbot A. Tew JG. The rolllcular dendritic cell: long term antigen retention during immunity, Immunol
Rev 1980;S3:29-S9, Liu YJ. Grouard G. de Bouteiller O, Bantliereau ), FoUicular dendritic cells and
germinal centers, Im Rev Cytology 1996;166:139-179. Steinman RM. ...
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rupress.org [HTML]… , SY Lee, B Sauter, HL Li, RM Steinman, Y … - The Journal of …, 1997 - jem.rupress.org
... Immunity. In press. ↵: Inaba, K,; MInaba,; NRomani,; HAya,; MDeguchi,; SIkehara,; SMuramatsu,;
RMSteinman. (1992) Generation of large numbers of dendritic cells from mouse bone marrow
cultures supplemented with granulocyte/macrophage colony–stimulating factor. ...
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... Immunity. In press. ↵: Inaba, K,; MInaba,; NRomani,; HAya,; MDeguchi,; SIkehara,; SMuramatsu,;
RMSteinman. (1992) Generation of large numbers of dendritic cells from mouse bone marrow
cultures supplemented with granulocyte/macrophage colony–stimulating factor. ...
Cited by 557 - Related articles - BL Direct - All 6 versions
nih.gov [HTML]… , E Bonvini, S Koenig, RM Steinman, … - Proceedings of the …, 2005 - National Acad Sciences
The final differentiation or maturation of dendritic cells (DCs) in response to environmental stimuli
influences their ability to both initiate immunity and determine the quality of the response to
antigens. Circulating immune complexes and cell-bound immunoglobulins present in ...
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The final differentiation or maturation of dendritic cells (DCs) in response to environmental stimuli
influences their ability to both initiate immunity and determine the quality of the response to
antigens. Circulating immune complexes and cell-bound immunoglobulins present in ...
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nih.gov [PDF]K Inaba, JP Metlay, MT Crowley, RM Steinman - ncbi.nlm.nih.gov
... By Kayo Inaba, Joshua P. Metlay, Mary T. Crowley, and Ralph M. Steinman ... generating
MHC-peptide complexes and pre- senting these to primed T cells, it is evident that the den- dritic
cell subset of APC greatly accelerates the early sensiti- zation phase of the immune response ...
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... By Kayo Inaba, Joshua P. Metlay, Mary T. Crowley, and Ralph M. Steinman ... generating
MHC-peptide complexes and pre- senting these to primed T cells, it is evident that the den- dritic
cell subset of APC greatly accelerates the early sensiti- zation phase of the immune response ...
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rupress.org [HTML]MK Brimnes, L Bonifaz, RM Steinman, … - The Journal of …, 2003 - jem.rupress.org
We evaluated the proposal that during microbial infection, dendritic cells (DCs) undergo maturation
and present a mixture of peptides derived from the microbe as well as harmless environmental
antigens. Mice were exposed to an aerosol of endotoxin free ovalbumin (OVA) in the ...
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We evaluated the proposal that during microbial infection, dendritic cells (DCs) undergo maturation
and present a mixture of peptides derived from the microbe as well as harmless environmental
antigens. Mice were exposed to an aerosol of endotoxin free ovalbumin (OVA) in the ...
Cited by 116 - Related articles - BL Direct - All 9 versions
JP Metlay, E Pure, RM Steinman - Adv Immunol, 1989 - books.google.com
ADVANCES IN IMMUNOLOGY, VOL. 47 Control of the Immune Response at the Level of
Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes
JOSHUA P. METLAY, ELLEN PURE, AND RALPH M. STEINMAN Rockefeller University ...
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ADVANCES IN IMMUNOLOGY, VOL. 47 Control of the Immune Response at the Level of
Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes
JOSHUA P. METLAY, ELLEN PURE, AND RALPH M. STEINMAN Rockefeller University ...
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RM Steinman, J Banchereau - Nature, 2007 - nature.com
... J. Exp. Med. 137, 1142–1162 (1973) | Article | PubMed | ISI | ChemPort |; Banchereau, J. &
Steinman, RM Dendritic cells and the control of immunity. Nature 392, 245–252 (1998) | Article |
PubMed | ISI | ChemPort |; Janeway, CA & Medzhitov, R. Innate immune recognition. Annu. ...
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... J. Exp. Med. 137, 1142–1162 (1973) | Article | PubMed | ISI | ChemPort |; Banchereau, J. &
Steinman, RM Dendritic cells and the control of immunity. Nature 392, 245–252 (1998) | Article |
PubMed | ISI | ChemPort |; Janeway, CA & Medzhitov, R. Innate immune recognition. Annu. ...
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rupress.org [HTML]… , B Moltedo, TM Moran, RM Steinman - The Journal of …, 2004 - jem.rupress.org
... Full Text. ↵ Fujii, S., K. Shimizu, C. Smith, L. Bonifaz, and RM Steinman. 2003. Activation of natural
killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo
and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a co ...
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... Full Text. ↵ Fujii, S., K. Shimizu, C. Smith, L. Bonifaz, and RM Steinman. 2003. Activation of natural
killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo
and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a co ...
Cited by 276 - Related articles - BL Direct - All 10 versions
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