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先来看下这个人的科研经历:
Current Position
Faculty, Department of Computer Science and Applied Mathematics
The Weizmann Institute of Science, Rehovot, Israel
Academic Background
1999-2004 Stanford University. Ph.D., Computer Science (Advisor: Daphne Koller)
1999-2004 Stanford University. Ph.D. minor, Genetics
1995-1998 Tel-Aviv University. B.Sc., Computer Science
Previous Position
2004-2005 Fellow, Center for Studies in Physics and Biology, Rockefeller University
经历很简单,也就是04年博士毕业的,”2004-2005 Fellow“相当于做了一年的博士后。
再来看下他从05年后发的文章
what controls nucleosome positions?
Eran Segal & Jonathan Widom
Trends Genet. 2009 Jul 9. [Epub ahead of print]
From DNA sequence to transcriptional behaviour: a quantitative approach
Eran Segal & Jonathan Widom
Nature Reviews Genetics, advance online publication, Published online 9 June 2009 (doi:10.1038/nrg2591)
Incorporating Nucleosomes into Thermodynamic Models of Transcription Regulation
Tali Raveh-Sadka, Michal Levo, Eran Segal
Genome Res. 2009. 19:1480-1496
The DNA-encoded nucleosome organization of a eukaryotic genome
Noam Kaplan, Irene K. Moore, Yvonne Fondufe-Mittendorf, Andrea J. Gossett, Desiree Tillo, Yair Field, Emily M. LeProust, Timothy R. Hughes, Jason D. Lieb, Jonathan Widom & Eran Segal
Nature 458, 362-366 (19 March 2009)
See also: Faculty of 1000 review
Poly(dA:dT) tracts: major determinants of nucleosome organization
Eran Segal and Jonathan Widom
Curr Opin Struct Biol. 2009 Feb;19(1):65-71. Epub 2009 Feb 7
Gene expression divergence in yeast is coupled to evolution of DNA-encoded nucleosome organization
Yair Field, Yvonne Fondufe-Mittendorf, Irene K. Moore, Piotr Mieczkowski, Noam Kaplan, Yaniv Lubling, Jason D. Lieb, Jonathan Widom & Eran Segal
Nature Genetics Published online: 1 March 2009 | doi:10.1038/ng.324
See also: Highlight in Nature Reviews Genetics, Faculty of 1000 review.
Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
Ophir Shalem, Orna Dahan, Michal Levo, Maria Rodriguez Martinez, Itay Furman, Eran Segal & Yitzhak Pilpel
Molecular Systems Biology 4 Article number: 4 doi:10.1038/msb.2008.59, Published online: 14 October 2008
See also: Faculty of 1000 review
Computational prediction of RNA structural motifs involved in posttranscriptional regulatory processes
Michal Rabani, Michael Kertesz, Eran Segal
Proc Natl Acad Sci U S A. 2008 Sep 24. [Epub ahead of print]
Preferentially Quantized Linker DNA Lengths in Saccharomyces cerevisiae
Ji-Ping Wang, Yvonne Fondufe-Mittendorf, Liqun Xi, Guei-Feng Tsai, Eran Segal, Jonathan Widom
PLoS Comput Biol 2008, September 12;4(9):e1000175
A Feature-Based Approach to Modeling Protein-DNA Interactions
Eilon Sharon, Shai Lubliner, Eran Segal.
PLoS Comput Biol 2008, August 22;4(8):e1000154
Geometric constraints on neuronal connectivity facilitate a concise synaptic adhesive code
Shalev Itzkovitz, Leehod Baruch, Ehud Shapiro, and Eran Segal
Proc Natl Acad Sci U S A. 2008 Jun 26. [Epub ahead of print]
Predicting expression patterns from regulatory sequence in Drosophila segmentation
Eran Segal, Tali Raveh-Sadka, Mark Schroeder, Ulrich Unnerstall & Ulrike Gaul
Nature 451, 535-540 (31 January 2008)
See also: Editor Summary
The role of site accessibility in microRNA target recognition
Michael Kertesz, Nicola Iovino, Ulrich Unnerstall, Ulrike Gaul & Eran Segal
Nature Genetics 39, 1278 - 1284 (2007).
See also: News & Views, Research Highlights
Decoding global gene expression programs in liver cancer by noninvasive imaging
Segal E, Sirlin CB, Ooi C, Adler AS, Gollub J, Chen X, Chan BK, Matcuk GR, Barry CT, Chang HY, Kuo MD
Nature Biotechnology 25, 675 - 680 (2007)
A module of negative feedback regulators defines growth factor signaling
Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB, Domany E, Yarden Y
Nature Genetics, 39, 503 - 512 (2007).
A Genomic Code for Nucleosome Positioning
E. Segal,Y. Fondufe-Mittendorf, L. Chen, A. Thastrom, Y. Field, I. K. Moore, J. Z. Wang, J. Widom.
Nature, 2006 July, 442(7104):772-8
See also: ESI Hot Paper, NY Times, Nature cover, News & Views, Nature Reviews Genetics, Faculty of 1000 review, Codes and Enigmas, TheScientist and about the authors.
Evidence for an instructive mechanism of de novo methylation in cancer cells.
I. Keshet., Y. Schlesinger, S. Farkash, E. Rand, M. Hecht, E. Segal, E. Pikarski, R.A. Young, A. Niveleau, H. Cedar, I. Simon.
Nature Genetics, 2006 February, 38(2): 149-53.
做传统的生物科学不可能能多产这么多。这么多的文章可能让我们一个国家汗颜,我看了他的这些文章后,我是非常惊讶,计算生物学的文章是不是让他一个人都写了,他主要做转录相关方面的工作,最近开始做表观遗传的相关工作。这些确实是近几年研究比较多的方向,也是近几年这方面的技术发展最迅速,新的技术出现使这个方向能出来很多东西,比如芯片。应该说做计算,我们中国人也是不差的,我们有很好的数学基础,为什么我们没有跟上,是不聪明,估计不是。
他的博士导师是Daphne Koller,在斯坦福计算机系教授,主要研究方向是机器学习及计算生物学。Daphne Koller也是以色列人,16岁拿到了硕士学位,她丈夫是EFI的CEO。Eran Segal在她哪也发了几篇分量比较重的文章,nature,science等杂志都有。
我想Eran Segal应该是在Koller哪学了一整套,后来就一发不可收拾,真佩服,什么时候我们也会有这样的牛人。
来自:http://genie.weizmann.ac.il/pubs/pubsall.html
http://robotics.stanford.edu/~koller/index.html
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