2024年12月18日，Elsevier 宣布旗下知名期刊《Chinese Chemical Letters》在线发表了云南师范大学化学化工学院吴相华、张俊峰教授的最新研究成果《A near-infrared II fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor》.云南师范大学化学化工学院吴相华、张俊峰教授为共同通讯作者。论文合作单位还有西南医科大学附属医院、

ABSTRACT

The fluorophores Xan-OH and Xan-OH/FBS, based on xanthene structure, possess an effective near-infrared absorption, near-infrared II (NIR-II) fluorescent imaging ability, and excellent photothermal property. Xan-OH/FBS also has good viscosity-sensitivity, enabling the real-time in vivo visualization of acute liver injury induced by CCl4. Moreover, the photothermal conversion coefficient of Xan-OH and Xan-OH/FBS under 808 nm laser irradiation are significant (27.53% and 26.77%, respectively), which could realize NIR-II fluorescence imaging-guided photothermal therapy for HeLa xenograft tumor. Given these promising characteristics, Xan-OH/FBS is an efficient NIR-II fluorescent imaging agent for acute liver injury and a potential photothermal therapeutic agent for tumor.

扩展阅读：

云南师范大学基础研究青年学者之--张俊峰

吴相华-云南师范大学化学化工学院

张俊峰-云南师范大学化学化工学院

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