▲ Vol 34 Issue 36 | 04 September, 2024

Chemokine-Based Injectable Navigation System for Enhancing CAR-T Cell Therapy Against Solid Tumors

Wenjun Wan, Wenqing Han, Jin Chen, Yangjing Li, Lei Zhao, Mengqian Gao, Cui Shen, Ning Liu, Wenhao Deng, Siqi Ma, Lifang Cheng, Yiran Zheng

CAR-T Cell Therapy

In article number 2401161, Yiran Zheng and co-workers present a chemokine-based Injectable platform for boosting adoptive T cells' efficacy (CITE). The system substantially promotes the tumor-specific migration of injected CAR-T cells and boosts the function of infiltrated T cells, thus improving the efficacies of CAR-T cell therapy to solid tumors. CITE also enhances systemic anti-tumor immunity and elicits immune memory, enabling CITE to treat multimodal and recurrent tumors. CITE is broadly applicable to adoptive cell therapies.

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202470209

▲ Vol 34 Issue 36 | 04 September, 2024

Supramolecular Electronics: Monolayer Assembly of Nonamphiphilic Molecules via Water Surface-Assisted Molecular Deposition

Jun Lim, Chuanhui Liu, Xiao Han, Menghan Tian, Baichuan Jiang, Wenbin Li, Cailing Ou, Nannan Dou, Zixiao Han, Tingyu Ji, Xiaoru Cao, Xiaolan Zhong, Lei Zhang

Utilizing softly confined self-assembly at the water surface represents a promising approach for the fabrication of two-dimensional molecular monolayers (2D MMs), which have predominantly been concentrated on amphiphilic organic compounds before. Herein, we introduce a straightforward method termed “water surface-assisted molecular deposition (WSAMD)” to organize nonamphiphilic molecules into dense monolayers with high reproducibility. To underscore the versatility and merit of this methodology in the field of supramolecular electronics, we have successfully fabricated a range of defect-free, uniform semiconducting polymer monolayers, featuring a thickness reflective of molecular architectures. The charge carrier mobility could reach 0.05 cm2 V–1 s–1 for holes and 3.5 × 10–4 cm2 V–1 s–1 for electrons, respectively, in p-type and n-type polymeric monolayers when tested as the active layer in field-effect transistors. Furthermore, in situ polymerization reactions can be exploited to generate conductive monolayers of macromolecules such as polybenzylaniline (PBnANI) and polypyrrole (PPy), where PBnANI monolayers exhibit channel length-dependent conductivity, up to 0.37 S cm–1. The advent of the WSAMD method heralds a significant leap forward in the advancement of molecular 2D materials, catalyzing new avenues of exploration within material chemistry.

https://pubs.acs.org/doi/10.1021/acsami.4c05552

<静远嘲风动漫传媒科技中心>设计制作

   购书链接：

☆科学的颜值：学术期刊封面故事及图像设计 

   https://item.jd.com/12802188.html

☆科技绘图/科研论文图/论文配图设计与创作自学手册：CorelDRAW篇 

   https://item.jd.com/13504674.html

☆科技绘图/科研论文图/论文配图设计与创作自学手册：Maya+PSP篇

   https://item.jd.com/13504686.html

☆科技绘图/科研论文图/论文配图设计与创作自学手册：科研动画篇

   https://item.jd.com/13048467.html#crumb-wrap

☆SCI图像语法-科技论文配图设计使用技巧

    https://item.jd.com/10073529532924.html?bbtf=1

静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。

学习更多绘图教程关注：