|
MCE 国际站:Sugammadex (sodium)
中文名:舒更葡糖钠
CAS:343306-79-6
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:Sugammadex sodium 是一种合成的 γ-环糊精衍生物,可作为神经肌肉阻滞的逆转剂。 Sugammadex sodium 在缺血再灌注损伤中表现出肾保护作用[1][2]。
体内:Sugammadex(100 mg/kg,IV,一次)在大鼠缺血一小时后开始再灌注时具有肾保护作用[2]。
动物体内实验:体重5.2-7.1kg的雌性恒河猴肌肉注射10mg/kg氯胺酮镇静。放置两根静脉管线:一根用于麻醉,包括罗库溴铵,另一根用于施用测试药物。随后静脉注射 25 mg/kg 戊巴比妥钠,随后连续输注 5-10 mg/kg/h。对猴子进行气管插管,用氧气和一氧化二氮的混合物(体积比为2:3)对肺部进行通气。四只动物分别在三个不同的场合进行研究。服用盐水或低剂量(1.0 mg/kg)或高剂量(2.5 mg/kg)舒更葡糖的场合有所不同。在两次实验之间,猴子的恢复时间至少为 6 周。使用脉搏血氧计在耳边测定心率和血氧饱和度。通过将袖带套在尾巴上来测定血压。通过直肠探针测量体温并保持在 37°C-38°C。
热销产品:Ezetimibe | L-Leucine | PF-9366 | NSC 74859 | Psoralidin | Midostaurin | S100A4, Mouse (His) | Tetrakis(triphenylphosphine)palladium | Atorvastatin | UNC1999
研究领域:Others
作用靶点:Others
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Tercan M, Yılmaz İnal F, Seneldir H, Kocoglu H. Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model. Cureus. 2021 Jun 17;13(6):e15726.
[2]. de Boer HD, et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology. 2006 Apr;104(4):718-23.
[3]. de Boer HD, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006 Apr;96(4):473-9. Epub 2006 Feb 7.
[4]. de Boer HD, et al. Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation. Br J Anaesth. 2006 Nov;97(5):681-6. Epub 2006 Oct 3.
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-9-27 08:53
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社