Dipotassium glycyrrhizinate | 甘草酸二钾

MCE 国际站：Dipotassium glycyrrhizinate

中文名：甘草酸二钾

CAS：68797-35-3

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：甘草酸二钾是一种天然化合物，可抑制特应性皮炎相关基因的表达，具有抗炎活性^[1]。

体外：Dipotassium glycyrrhizinate (0-400 μM，4 天) 抑制 IL-4 和 IL-13 诱导的角质形成细胞中特应性皮炎相关基因 (NELL2、CA2、AQP3 和 HAS3 基因水平) 的 mRNA 水平[1]。 Dipotassium glycyrrhizinate (0-400 μM，4 天) 部分修复了 IL-4/IL-13 诱导的 AD 样皮肤等效模型中的特应性皮炎样表型(海绵状细胞间隙)[1]。 Dipotassium glycyrrhizinate (0-100 μM，24 小时) 抑制舒尼替尼诱导的 CCC-HEH-2 细胞自噬和心肌细胞死亡[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Dipotassium glycyrrhizinate (150 mg/kg，腹腔注射) 可降低链脲佐菌素 (65 mg/kg，腹腔注射) 诱导的 1 型糖尿病大鼠的血浆葡萄糖并增加血浆 GLP-1 水平[2]。 Dipotassium glycyrrhizinate (50 mg/kg，腹腔注射，每日一次，持续 4 周) 可抑制碘诱导的自身免疫性甲状腺炎小鼠模型中的甲状腺炎[3]。 Dipotassium glycyrrhizinate (50-200 mg/kg，腹腔注射) 可抑制博莱霉素 (HY-108345) 诱导的大鼠肺纤维化[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Iodine-induced murine model of autoimmune thyroiditis[3] Dosage: 50 mg/kg Administration: i.p., once daily for 4 weeks Result: Reduced serum levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β. Decreased The prevalence of thyroiditis and the infiltration of lymphocytes, and attenuated the severity of thyroiditis. Clinical Trial

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研究领域：Anti-infection

作用靶点：Virus Protease

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参考文献：[1]. Lee SH, et al. Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model. Arch Dermatol Res. 2019 Mar;311(2):131-140.

[2]. Wang LY, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Nov;95:599-604. 

[3]. Li C, et al. Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27(5):722-731.[4]. Xu Z, et al. Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib. Autophagy. 2022 May;18(5):1152-1173.[5]. Gao L, et al. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats. Front Pharmacol. 2015 Oct 1;6:215.