Esomeprazole magnesium | 埃索美拉唑镁

MCE 国际站：Esomeprazole magnesium

中文名：埃索美拉唑镁

CAS：161973-10-0

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：Esomeprazole magnesium ((S)-Omeprazole magnesium) 是一种有效的口服活性 H⁺, K⁺-ATPase 抑制剂。埃索美拉唑镁具有用于上肠道疾病和胃食管反流病研究的潜力^[1][2]。 Esomeprazole magnesium 通过抑制 VH⁺-ATPases^[4] 来阻断外泌体释放，从而充当外泌体抑制剂。 IC50 和目标：H⁺、K⁺-ATPase^[1]  

体外：Esomeprazole magnesium 是 H⁺, K⁺-ATPase^[1] 的抑制剂。Esomeprazole magnesium 由 Esomeprazole 锶四水合物 (EST) 发展而来。 EST 包含埃索美拉唑，奥美拉唑的 S-对映异构体，是埃索美拉唑镁三水合物的盐交换形式^[3]。

体内：埃索美拉唑镁（0.5-50 mg/kg；口服强饲法；每日一次；持续 10 天；A/J 小鼠）处理增加胃总抗氧化能力和 Cu/Zn-超氧化物歧化酶活性^[1]。

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研究领域：Membrane Transporter/Ion Channel

作用靶点：Proton Pump

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参考文献：[1]. 2013 Annual Meeting. Abstract Supplement[

2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

[3]. Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5(3):243-56.

[4]. Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.