L-Alanosine | 丙氨菌素

MCE 国际站：L-Alanosine

中文名：丙氨菌素

CAS：5854-93-3

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years.

生物活性：L-Alanosine (NSC-153353) 是一种来自 Streptomyces alanosinicus 的抗生素，具有抗肿瘤活性。 L-Alanosine (NSC-153353) 抑制腺苷酸合成酶，后者将肌苷单磷酸 (IMP) 转化为腺苷酸。 L-Alanosine (NSC-153353) 阻断常见的嘌呤从头生物合成途径，从而抑制 MTAP 缺陷的肿瘤细胞^{[1][2][ 3]}。

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研究领域：Anti-infection

作用靶点：Antibiotic

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参考文献：[1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21.

[2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20.

[3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7.