8-CPT-Cyclic AMP (sodium)

MCE 国际站：8-CPT-Cyclic AMP (sodium)

CAS：93882-12-3

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：8-CPT-Cyclic AMP (8-CPT-cAMP) sodium 是 cyclic AMP-dependent protein kinase (PKA) 的选择性激活剂。 8-CPT-Cyclic AMP sodium 也是环 GMP 特异性磷酸二酯酶 (PDE VA) 的有效抑制剂，IC₅₀ 为 0.9微米。 8-CPT-Cyclic AMP sodium 还抑制 PDE III 和 PDE IV，IC₅₀Epac 具有很高的亲和力，是一种有效的 Epac 激活剂^[1][2] 。 

体外：a-Fas 和 TNF-α/CHX 可迅速（在 2 小时内）诱导中性粒细胞死亡至少 90%。常用的 cAMP 类似物 8-pCPT-cAMP (0.7 mM) 可延迟 TNF-/CHX 诱导和 a-Fas 诱导的细胞凋亡。它对 TNF-/CHX 诱导的细胞凋亡比对 a-Fas^[2] 更有效。

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研究领域：TGF-beta/Smad  |  Stem Cell/Wnt  |  Metabolic Enzyme/Protease

作用靶点：PKA  |  Phosphodiesterase (PDE)

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参考文献：[1]. Connolly BJ, et al. 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem Pharmacol. 1992;44(12):2303-2306.

 [2]. Krakstad C, et al. cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). J Leukoc Biol. 2004;76(3):641-647.