Vasopressin

MCE 国际站：Vasopressin

CAS：11000-17-2

品牌：MedChemExpress (MCE)

存储条件：polypeptide, sealed storage, away from moisture

生物活性：加压素是一种在下丘脑中枢合成的环状九肽。加压素参与下丘脑-垂体-肾上腺轴，并通过增强促肾上腺皮质激素释放因子的刺激作用来调节垂体促肾上腺皮质激素的分泌。加压素还可以作为一种神经递质，通过与特定的 G 蛋白偶联受体结合发挥作用^[1][2][3] .  

体外：AVP (0.01 nM-1 μM) 诱导表达大鼠或人 V_1b 受体^[2] 的中国仓鼠卵巢细胞中的 Ca²⁺ 增加。

体内：血管加压素（0.03-0.3 μg/kg；腹腔注射）增强由外源性皮质醇引起的促肾上腺皮质激素释放，并增加体内水分流失后促肾上腺皮质激素的分泌^[2]。血管加压素（0.001-0.1 mg/kg ; ip) 有效地增加了相邻的躺卧，第一次见面的老鼠被动地挨着躺着^[3]。

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研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

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参考文献：[1]. Baribeau DA, et, al. Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits. Front Neurosci. 2015 Sep 24;9:335.

[2]. Ramos L, et, al. Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor. Neuropsychopharmacology. 2013 Oct;38(11):2249-59.

[3]. Gal CSL, et, al. Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30.