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MCE 国际站:Pyridoxal phosphate
中文名:磷酸吡哆醛
CAS:54-47-7
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Pyridoxal phosphate 是维生素 B6 的活性形式,可作为逆转录酶的抑制剂,用于治疗迟发性运动障碍。
体外:Pyridoxal 5'-phosphate 严重抑制 DNA 聚合酶和 RNase H。Pyridoxal phosphate 导致 DNA 合成速率立即降低[1]。与磷酸吡哆醛结合可完全抑制 NEIL2。在广泛的酶/底物比率范围内,磷酸吡哆醛缀合的 NEIL2 显示出比完整酶低得多的活性。磷酸吡哆醛缀合后,NEIL2 结合 THF 配体的能力完全丧失[2]。
热销产品:Lucifer Yellow CH (dipotassium salt) | G140 | CX-5461 | SAR405 | Fostamatinib | E 2012 | Sunvozertinib | CRT0066101 (dihydrochloride) | Birabresib | BiP inducer X
研究领域:Anti-infection | Metabolic Enzyme/Protease
作用靶点:Reverse Transcriptase | Endogenous Metabolite
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.
[2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.
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