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Sodium 2-mercaptoethanesulfonate | 美司钠
MCE 国际站:Sodium 2-mercaptoethanesulfonate
中文名:美司钠
CAS:19767-45-4
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:Mesna (Sodium 2-mercaptoethanesulfonate) 是一种具有细胞保护作用的抗氧化剂。美司钠被广泛用作抗化疗毒性的全身保护剂。 Mesna 还用于减轻环磷酰胺[1][2] 引起的出血性膀胱炎。
体外:Mesna (1-1000 μM) 以剂量依赖性方式降低 H2O2、HOCl 和 OH• 浓度,IC50在无细胞实验中分别为 32、21 和 305 μM[3]。
体内:Mesna(150 mg/kg;单次 ip)保护大鼠脑免受外伤[1]。Mesna(200 mg/kg;单次 ip)减弱顺铂诱导的卵巢功能障碍大鼠的损伤[2]。
热销产品:Amphotericin B | 27-Hydroxycholesterol | Metoprolol | Icaritin | AV-105 | Crizotinib | Fruquintinib | Lovastatin | Telotristat etiprate | Leptomycin B
研究领域:Others
作用靶点:Others
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参考文献:[1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149.
[2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85.
[3]. Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17(3):76-80.
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