Oroxylin A | 千层纸素A

MCE 国际站：Oroxylin A

中文名：千层纸素A

CAS：480-11-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性： Oroxylin A 是一种天然活性黄酮类化合物，具有很强的抗癌作用。 IC50 值：目标：体外：Oroxylin A 通过下调 wt-p53 癌细胞中的 MDM2 转录来抑制 MDM2 介导的 p53 降解 [1]。 Oroxylin A 显着降低 HepG2 细胞缺氧条件下乳酸的生成和葡萄糖的摄取，抑制 HIF-1α 的表达及其稳定性 [2]。 Oroxylin A 通过 SIRT3 调节的 FOXO3a DNA 结合活性促进超氧化物歧化酶 (SOD2) 基因表达，并通过促进 SIRT3 介导的脱乙酰化来增加 SOD2 的活性 [3]。体内：Oroxylin A 抑制裸鼠接种的 MCF-7 或 HCT116 细胞的肿瘤生长。 oroxylin A 也可下调肿瘤组织中 MDM2 蛋白的表达 [1]。

体外：Oroxylin A (20 μM; 24 h) 抑制 MDA-MB-231 细胞的生长、增殖、迁徙。Oroxylin A 还抑制 MDA-MB-231 的侵袭，抑制其上皮-间质转化 (EMT) 过程[4]。Oroxylin A (20 μM; 24 h) 还抑制促炎细胞因子表达，抑制 NF-κB 信号通路[4]。Oroxylin A 的抗炎作用会被 TNF-α 消弭[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：Metabolic Enzyme/Protease  |  Autophagy  |  Anti-infection

作用靶点：HIF/HIF Prolyl-Hydroxylase  |  Autophagy  |  Virus Protease

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参考文献：[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914

[2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10.

[3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9

[4]. Sun X, et al. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. Biomed Res Int. 2019 Jun 23;2019:9241769.

[5]. Yang X, et al. Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. Inflamm Bowel Dis. 2013 Aug;19(9):1990-2000.