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MCE 国际站:Minoxidil
中文名:米诺地尔
CAS:38304-91-5
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Minoxidil (U10858) 是一种ATP 敏感性钾 (KATP) 通道 开启剂,是一种有效的口服降压药和外周血管扩张剂,可促进血管舒张并影响毛发生长。 Minoxidil 也是一种有效的大豆脂肪氧化酶抑制剂,IC50 为 20 μM[1] [2][3]。 IC50 和目标:IC50:20 μM(大豆脂肪氧化酶)[1]; ATP 敏感性钾通道[2]
体外:米诺地尔(1-00 µM;24 小时;RAMEC 细胞)处理在检测的整个浓度区域(从 1 µM 到 100 µM)显示出非常低的细胞毒性[1]。
体内:米诺地尔(0.01 mmoL/kg 体重;腹腔注射;持续 3.5 小时;Fisher 344 只大鼠)处理抑制角叉菜胶诱导的大鼠爪水肿,抑制效力 (49%)[1]。
热销产品:Amivantamab | Temozolomide | Aldosterone | Mirvetuximab soravtansine | Pexidartinib | Prostaglandin E2 | Pembrolizumab | DAPT | Pilocarpine (Hydrochloride) | Ibrutinib
研究领域:Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点:Potassium Channel | Endogenous Metabolite
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95(7):1437-49. doi: 10.1016/j.biochi.2013.03.009. Epub 2013 Mar 28.
[2]. Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124(4):686-94.
[3]. Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82(1):90-3.
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