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Se-Methylselenocysteine | L-硒甲基硒代半胱氨酸
MCE 国际站:Se-Methylselenocysteine
中文名:L-硒甲基硒代半胱氨酸
CAS:26046-90-2
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Se-Methylselenocysteine 是甲基硒醇的前体,具有有效的癌症化学预防活性和抗氧化活性。 Se-Methylselenocysteine 具有口服生物利用度,可诱导细胞凋亡[1][2]。
体外:Se-Methylselenocysteine(100-400 μM;3 天)诱导 SKOV-33 细胞凋亡[1]。Se-Methylselenocysteine(100-400 μM;3 天)诱导 caspase-3介导的细胞凋亡[1]。
体内:Se-Methylselenocysteine(0.2 mg/只小鼠;口服;每日一次,持续 14 天)在携带人 FaDu 和 A253 头颈异种移植物的裸鼠中增强 CDDP 和环磷酰胺的抗肿瘤活性[2]。阿尔茨海默氏病 (AD) 小鼠在其饮用水中加入硒-甲基硒代半胱氨酸(每天 0.75 毫克/千克体重)治疗 10 个月。 Se-Methylselenocysteine 减少氧化应激和神经炎症; Se-Methylselenocysteine 调节多种金属离子的分布和水平; Se-Methylselenocysteine 通过抑制其前体蛋白 APP 和 β-分泌酶 (BACE1) 的表达来减少淀粉样蛋白-β 肽 (Aβ) 的生成,并通过促进蛋白磷酸酶 2A (PP2A) 活性来减弱 tau 过度磷酸化和神经原纤维缠结 (NFT) 的形成,从而保护突触蛋白和神经元活动,最终改善 AD 模型小鼠的空间学习和记忆缺陷[3]。
热销产品:Trilostane | BMS-582949 (hydrochloride) | Danirixin | Betaxolol (hydrochloride) | Phyllanthin | Lansoprazole sulfone | Dutasteride | SAR405838 | Adarotene | Calmodulin-Dependent Protein Kinase II(290-309) (acetate)
研究领域:Apoptosis | Metabolic Enzyme/Protease | Neuronal Signaling
作用靶点:Apoptosis | Endogenous Metabolite | Beta-secretase
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.
[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.
[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.
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