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MCE 国际站:Spironolactone
中文名:螺内酯
CAS:52-01-7
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Spironolactone (SC9420) 是一种具有口服活性的醛固酮盐皮质激素受体拮抗剂,IC50 为 24 nM。 Spironolactone 也是一种有效的雄激素受体拮抗剂,IC50 为 77 nM。螺内酯促进足细胞[1][2][3]中的自噬。
热销产品:Oxypeucedanin | Talmapimod | Gypsogenin | BS-181 (hydrochloride) | Carmine | Ribonuclease A | Camelliaside A | Glemanserin | Melanotan (MT)-II | Deltonin
研究领域:Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Autophagy
作用靶点:Mineralocorticoid Receptor | Androgen Receptor | Autophagy
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5(3):37-50.
[2]. Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285(39):29932-29940.
[3]. Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51(4):755-764.
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