Spironolactone | 螺内酯

MCE 国际站：Spironolactone

中文名：螺内酯

CAS：52-01-7

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Spironolactone (SC9420) 是一种具有口服活性的醛固酮盐皮质激素受体拮抗剂，IC₅₀ 为 24 nM。 Spironolactone 也是一种有效的雄激素受体拮抗剂，IC₅₀ 为 77 nM。螺内酯促进足细胞^[1][2][3]中的自噬。

热销产品：Oxypeucedanin  | Talmapimod  | Gypsogenin  | BS-181 (hydrochloride)  | Carmine  | Ribonuclease A  | Camelliaside A  | Glemanserin  | Melanotan (MT)-II  | Deltonin

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor  |  Autophagy

作用靶点：Mineralocorticoid Receptor  |  Androgen Receptor  |  Autophagy

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5(3):37-50.

[2]. Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285(39):29932-29940.

[3]. Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51(4):755-764.