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MCE 国际站:116-9e
CAS:831217-43-7
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:116-9e (MAL2-11B) 是一种 Hsp70 co-chaperone DNAJA1 抑制剂。 116-9e 抑制猿猴病毒 40 (SV40) 复制和DNA 合成。 116-9e 抑制肿瘤抗原 (TAg) 的内源性 ATP 酶活性和 TAg 介导的 Hsp70 激活[1][2]。 IC50 和目标:猿猴病毒 40 (SV40) [1]Hsp70 协同伴侣 DNAJA1[2]
体外:116-9e (MAL2-11B) 抑制 Hsp70 的 TAg 刺激比 MAL3-101 更有效,显着减少病毒复制和 DNA 合成。 MAL2-11B 还抑制 TAg ATPase 结构域的活性[1]。116-9e(MAL2-11B;15 µM;5 天)显着降低 BK 病毒在人肾细胞系[1].
热销产品:Safinamide | BAY1217389 | ALLM | Dabigatran etexilate | Schisantherin B | Methyl 4-boronobenzoate | GNE-6640 | DL-Mevalonolactone | Collagens | Ginsenoside Rc
研究领域:Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点:HSP | DNA/RNA Synthesis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80.
[2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831.
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