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MCE 国际站:3-Indolepropionic acid
CAS:830-96-6
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:3-Indolepropionic acid 被证明是一种强大的抗氧化剂,并具有治疗阿尔茨海默病的潜力。
体外:3-吲哚丙酸被证明是一种强大的抗氧化剂,在治疗阿尔茨海默病方面具有潜力[1]。 3-吲哚丙酸是一种比褪黑激素更有效的羟基自由基清除剂。与褪黑激素类似,但与其他抗氧化剂不同,3-吲哚丙酸清除自由基后不会产生活性和促氧化中间化合物[2]。还表明,肠道微生物群产生的代谢物吲哚丙酸是 2 型糖尿病 (T2D) 发展的潜在生物标志物,可能通过保护 β 细胞功能介导其保护作用[3]。
热销产品:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | SPB | Tamibarotene | CITCO | Relugolix | Cefoperazone | LCMV gp33-41 | H-Phe(4-Ac)-OH | 3-Nitropropanoic acid | Demeclocycline
研究领域:Metabolic Enzyme/Protease | NF-κB | Immunology/Inflammation
作用靶点:Endogenous Metabolite | Reactive Oxygen Species
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Wikoff WR, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703.
[2]. Reiter RJ, et al. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998 Nov 20;854:410-24.
[3]. de Mello VDet al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337.
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