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MCE 国际站:Meropenem
中文名:美罗培南
CAS:96036-03-2
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Meropenem (SM 7338) 是一种碳青霉烯类抗生素,具有广谱抗菌活性。美罗培南对易感和抗性 N 具有活性。淋球菌(MIC 值为 0.02-0.06 mg/mL),H.流感(MIC 值为 0.03-0.12 mg/mL)和 H. ducreyi(MIC 值为 0.015-0.12 mg/mL)[1][2]。
体外:美罗培南对脱氢肽酶 1 (DHP-1) 的降解本质上是稳定的,美罗培南通过结合青霉素结合蛋白 (PBP) 并使其失活来抑制细菌细胞壁的合成。美罗培南具有广谱的体外活性,包括对许多革兰氏阳性菌、革兰氏阴性菌和厌氧菌的活性;美罗培南对粪肠球菌、耐甲氧西林金黄色葡萄球菌和嗜麦芽窄食单胞菌[2]缺乏活性。
体内:美罗培南(60 mg/kg;腹腔注射;一次;SD大鼠)治疗显着降低了胰腺感染的发生率[3]。
热销产品:Metipranolol | A-3 (hydrochloride) | Encainide | Bromoacetamido-PEG5-azide | Benzoylaconine | Dihydromethysticin | Sepimostat | Sulconazole (mononitrate) | Forchlorfenuron | Gadopentetate (dimeglumine)
研究领域:Anti-infection
作用靶点:Penicillin-binding protein (PBP) | Bacterial | Antibiotic
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. L Slaney, et al. In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother. 1989 Sep;24 Suppl A:183-6.
[2]. George G Zhanel, et al. Comparative review of the carbapenems. Drugs. 2007;67(7):1027-52.
[3]. Umit Ateskan, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas. 2003 Oct;27(3):247-52.
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