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Guanidine (hydrochloride) | 盐酸胍
MCE 国际站:Guanidine (hydrochloride)
中文名:盐酸胍
CAS:50-01-1
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:盐酸胍(Guanidinium chloride)是一种强离液剂,也是一种强蛋白质变性剂[1][2]。
体外:低浓度的盐酸胍重新折叠酸解折叠的脱肌红蛋白和细胞色素 c,稳定熔球状态,即具有大量二级结构但基本上无序的三级结构的致密变性状态。盐酸胍 (> 1 M) 引起熔融球态的协同展开[1]。由于二硫键的存在,相当程度的有序结构得以保留,盐酸胍不影响[2]。毫摩尔浓度的盐酸胍能够导致酵母细胞中通常稳定的 [PSI+] 元素的有效损失。生长培养基中的 5 mM Guanidine hydrochloride 可治愈 [PSI+] 和其他酵母朊病毒。 5 mM Guanidine hydrochloride 显着降低 Hsp104 介导的基础和获得性耐热性,分别降低 30 倍和 50 倍。 Guanidine hydrochloride 还会降低 Hsp104 恢复热变性荧光素酶活性的能力[3]。
体内:感染 10 LD50) 柯萨奇病毒 A16 的幼鼠在感染后 58 小时接受两次 145 mg/kg 每次注射盐酸胍治疗<支持>[4]。
热销产品:PD 407824 | Cloprostenol sodium salt | Emodin-8-glucoside | Acetaminophen metabolite 3-hydroxy-acetaminophen | Fustin | Protirelin | Bulleyaconitine A | Hydroxyethyl starch | Econazole | Daucosterol
研究领域:Metabolic Enzyme/Protease
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.
[2]. G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43(1):7-10.
[3]. Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1339-44.
[4]. E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2(6):339-46.
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