L-Methionine | L-蛋氨酸

MCE 国际站：L-Methionine

中文名：L-蛋氨酸

CAS：63-68-3

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：L-蛋氨酸是蛋氨酸的左旋异构体，蛋氨酸是人类发育必需的氨基酸。甲硫氨酸充当保肝剂。

体外：L-Methionine (5 mg/mL, 7 或 3 天) 可抑制 BXPC-3 (突变型 p53) 和 HPAC (野生型 p53) 胰腺癌细胞增殖，干扰细胞周期，诱导 BXPC-3 细胞凋亡[1]。 L-Methionine (0.3-10 mM, 24 h) 通过诱导血红素氧化酶-1和铁蛋白来减少内皮细胞中自由基的形成[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：L-Methionine (215, 268.8, 322.5, 430 mg/kg, 口服, 连续 14 天) 通过激活 Nrf2-ARE 通路，诱导内源性抗氧化活性，抑制生长大鼠 ROS 源性氧化应激[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (body weight 70-80 g)[3] Dosage: 215,268.8, 322.5, 430 mg/kg Administration: p.o. Result: Reduced the hepatic ROS levels and the hepatic MDA contents. Increased the hepatic T-AOC, CAT and T-SOD. Increased the hepatic activity of GCL, GR, GST and GPx.

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研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

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