Acivicin hydrochloride 是 Streptomyces sviceus 产生的天然产物

https://blog.sciencenet.cn/blog-3536222-1444659.html

1. The mouse bone marrow micronucleus test: evaluation of 21 drug candidates.

C S Aaron,R Sorg,D Zimmer

Upjohn Company, Kalamazoo, MI 49001.

Mutat Res (P 0027-5107 E 0027-5107) H指数：0 1989 年 223 卷 2 期 129-40 页

PMID：2525668 相似文献

http://www.pubmedplus.cn/P/SearchQuickResult?wd=daa52e77-e465-40a2-811a-39e7f9920fac

http://www.pubmedplus.cn/P/SearchQuickResult?wd=566e6425-49b2-4386-9f2f-2b9258e93319

• 主题词

• 记录数占%

https://pubmed.ncbi.nlm.nih.gov/2525668/

Mutat Res

. 1989 Jun;223(2):129-40.

 doi: 10.1016/0165-1218(89)90041-4.

The mouse bone marrow micronucleus test: evaluation of 21 drug candidates

C S Aaron 1, R Sorg, D Zimmer

Affiliations expand

• PMID: 2525668

•  

• DOI: 10.1016/0165-1218(89)90041-4

Abstract

The mouse bone-marrow micronucleus test is one of the most widely used genetic toxicology assays. In this report the results of testing 21 compounds in the micronucleus test are presented. Of the 21 compounds tested, 3 potential chemotherapeutic agents were identified as strongly clastogenic. In addition, one compound was identified as a weak inducer of micronuclei in the assay. Further testing of this compound in an in vivo bone marrow metaphase analysis failed to confirm this material as clastogenic. The remaining 17 compounds were classified as negative in the assay. In general the results of the micronucleus test agreed with the results of other genetic toxicology assays on this group of compounds.

PubMed Disclaimer

Similar articles

• In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test.

  Gebel T, Kevekordes S, Pav K, Edenharder R, Dunkelberg H.Arch Toxicol. 1997;71(3):193-7. doi: 10.1007/s002040050375.PMID: 9049057

• The in vivo gut micronucleus test detects clastogens and aneugens given by gavage.

  Vanhauwaert A, Vanparys P, Kirsch-Volders M.Mutagenesis. 2001 Jan;16(1):39-50. doi: 10.1093/mutage/16.1.39.PMID: 11139597

• The performance of short-term tests in identifying potential germ cell mutagens: a qualitative and quantitative analysis.

  Waters MD, Stack HF, Jackson MA, Bridges BA, Adler ID.Mutat Res. 1994 Dec;341(2):109-31. doi: 10.1016/0165-1218(94)90093-0.PMID: 7527489

• Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.

  Morita T, Asano N, Awogi T, Sasaki YF, Sato S, Shimada H, Sutou S, Suzuki T, Wakata A, Sofuni T, Hayashi M.Mutat Res. 1997 Feb 28;389(1):3-122. doi: 10.1016/s1383-5718(96)00070-8.PMID: 9062586 Review.

• Micronucleus assays in rodent tissues other than bone marrow.

  Morita T, MacGregor JT, Hayashi M.Mutagenesis. 2011 Jan;26(1):223-30. doi: 10.1093/mutage/geq066.PMID: 21164206 Review.

See all similar articles

Cited by

• Improved Safety, Bioavailability and Pharmacokinetics of Zidovudine through Lactoferrin Nanoparticles during Oral Administration in Rats.

  Kumar P, Lakshmi YS, C B, Golla K, Kondapi AK.PLoS One. 2015 Oct 13;10(10):e0140399. doi: 10.1371/journal.pone.0140399. eCollection 2015.PMID: 26461917 Free PMC article.

• End points for biomonitoring: assay sensitivity/selectivity.

  Aaron CS, Zimmer DM, Harbach PR, Yu RL.Environ Health Perspect. 1996 May;104 Suppl 3(Suppl 3):521-5. doi: 10.1289/ehp.96104s3521.PMID: 8781375 Free PMC article.

MeSH terms

• Animals

• Antibiotics, Antineoplastic

• Benzofurans

• Bone Marrow / drug effects

• Bone Marrow / ultrastructure

• Cyclohexanecarboxylic Acids / toxicity

• Cyclohexenes

• Duocarmycins

• Female

• Indoles*

• Isoxazoles / toxicity

• Male

• Menogaril

• Mice

• Micronucleus Tests*

• Mutagens*

• Nogalamycin / analogs & derivatives

• Nogalamycin / toxicity

• Piperazines / toxicity

• Structure-Activity Relationship

Substances

• Antibiotics, Antineoplastic

• Benzofurans

• Cyclohexanecarboxylic Acids

• Cyclohexenes

• Duocarmycins

• Indoles

• Isoxazoles

• Mutagens

• Piperazines

• adozelesin

• Menogaril

• losulazine hydrochloride

• Nogalamycin

• acivicin

Related information

• MedGen

• PubChem Compound (MeSH Keyword)

LinkOut - more resources

• Full Text Sources

• Elsevier Science