AGI-24512 是一种有效的甲硫氨酸腺苷转移酶 2α (MAT2A) 抑制剂 

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• 1. S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma.

  Yanmeng Wang,Catharina Muylaert,Arne Wyns,Philip Vlummens,Kim De Veirman,Karin Vanderkerken,Esther Zaal,Celia Berkers,Jérome Moreaux,Elke De Bruyne,Eline Menu

  Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel - Jette.

  Elke.De.Bruyne@vub.be

  Haematologica (P 1592-8721 E 0390-6078) H指数：125 2024 年 109 卷 1 期 256-271 页

  PMID：37470139 相似文献

  文摘 DOI链接 Pagepress Publications

• 2. MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.

  Peter Kalev,Marc L Hyer,Stefan Gross,Zenon Konteatis,Chi-Chao Chen,Mark Fletcher,Max Lein,Elia Aguado-Fraile,Victoria Frank,Amelia Barnett,Everton Mandley,Joshua Goldford,Yue Chen,Katie Sellers,Sebastian Hayes,Kate Lizotte,Phong Quang,Yesim Tuncay,Michelle Clasquin,Rachel Peters,Jaclyn Weier,Eric Simone,Joshua Murtie,Wei Liu,Raj Nagaraja,Lenny Dang,Zhihua Sui,Scott A Biller,Jeremy Travins,Kevin M Marks,Katya Marjon

  Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.

  katya.marjon@agios.com

  Cancer Cell (P 1878-3686 E 1535-6108) H指数：295 2021 年 39 卷 2 期 209-224.e11 页

  PMID：33450196 相似文献

https://pubmed.ncbi.nlm.nih.gov/37470139/

Haematologica

. 2024 Jan 1;109(1):256-271.

 doi: 10.3324/haematol.2023.282866.

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma

Yanmeng Wang 1, Catharina Muylaert 1, Arne Wyns 1, Philip Vlummens 2, Kim De Veirman 1, Karin Vanderkerken 1, Esther Zaal 3, Celia Berkers 3, Jérome Moreaux 4, Elke De Bruyne 5, Eline Menu 6

Affiliations expand

• PMID: 37470139

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• PMCID: PMC10772537

•  

• DOI: 10.3324/haematol.2023.282866

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