|
MCE 国际站:CP-316819
CAS:186392-43-8
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:CP 316819 是一种有效的糖原磷酸化酶 (GPase) 抑制剂,具有抗高血糖作用(IC50 对人骨骼肌糖原磷酸化酶的值分别为 17 和 34 nM (huSMGPa) 和肝糖原磷酸化酶 (huLGPa)。CP 316819 在正常血糖条件下引起糖原积累,但在葡萄糖浓度低时允许糖原利用。CP-316819 防止神经元细胞死亡并维持脑电流[1][2]。
热销产品:R-spondin 3, Human (125aa, HEK293, His) | Trigonelline | Triciribine | Codrituzumab | Coenzyme Q9 | Fosmidomycin sodium salt | WSP-1 | Stearoylcarnitine | LEP(116-130)(mouse) | Prazosin (hydrochloride)
研究领域:Others
作用靶点:Others
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Baker DJ, Timmons JA, Greenhaff PL. Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes. 2005 Aug;54(8):2453-9.
[2]. Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA. Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-7-31 14:19
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社