p-SCN-Bn-DOTA

国际站：p-SCN-Bn-DOTA

CAS：127985-74-4

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：p-SCN-Bn-DOTA 是一种双功能螯合剂。 p-SCN-Bn-DOTA可同时螯合放射性核素和连接单克隆抗体用于肿瘤放射免疫治疗^[1][2]。 

体外：p-SCN-Bn-DOTA 与 5 种不同的金属离子络合：In(III)、Y(III)、Lu(III)、Gd(III) 和 Cu(II)^[2]。

参考文献：[1]. Vera DRB, et, al. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26(3):287-97.[2]. Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253.