CAS：2089251-47-6

品牌：MedChemExpress (MCE)

存储条件：Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：SM-102 是一种可电离的氨基脂质，可用于形成脂质纳米粒子 (LNPs)^[1]。 SM-102 具有开发用于递送基于 mRNA 的疫苗的脂质纳米颗粒的潜力^[2]。

体外：SM-102 (100-300 µM, 1 分钟) 浓度依赖性地抑制 GH3 细胞中 Erg 介导的 K+ 电流 (IK(erg)) 幅度[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献：

[1]. Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.

[2]. Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065.

[3]. Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6(undecyloxy)hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9(10):1367.